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Peripheral Artery Disease (PAD) Research

05:31 EDT 25th June 2019 | BioPortfolio

Retrieved Arterial Clot Helps Guide Antibiotic Therapy in Infective Endocarditis.

Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease.

Extracellular vesicles (EVs) harbor thousands of proteins that hold promise for biomarker development. Usually difficult to purify, EVs in urine are relatively easily obtained and have demonstrated efficacy for kidney disease prediction. Herein, we further characterize the proteome of urinary EVs to explore the potential for biomarkers unrelated to kidney dysfunction, focusing on Parkinson's disea...

Impact of Adult Mosquito Control on Dengue Prevalence in a Multi-patch Setting: A Case Study in Kolkata (2014-2015).

Dengue is one of the deadliest mosquito-borne disease prevalent mainly in tropical and sub-tropical regions. Controlling the spread of this disease becomes a major concern to the public health authority. World Health Organization (WHO) adopted several mosquito control strategies to reduce the disease prevalence. In this work, a general multi-patch non-autonomous dengue model is formulated to captu...

Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: the African American Eye Disease Study.

To determine the relationship between systemic factors and radial peripapillary capillary (RPC) vessel density (VD) in healthy African American (AA) participants of the African American Eye Disease Study.

Optimal control of a Multi-patch Dengue Model under the Influence of Wolbachia Bacterium.

In this work, a multi-patch model for dengue transmission dynamics including the bacterium Wolbachia is studied and by that the control efforts to minimize the disease spread by host and vector control are investigated. The multi-patch system models the host movement within the patches which coupled via a residence-time budgeting matrix P. Numerical results confirm that the control mechanism embed...

A simple and effective method for the isolation and culture of human monocytes from small volumes of peripheral blood.

Innate immune cell defects contribute to severe autoimmunity and the pathogenesis of inflammatory disease. Monocyte-derived macrophages typically retain disease related signatures and represent an excellent in vitro model to uncover and validate mechanisms contributing to specific pathological states. Monocyte isolation procedures vary widely in terms of purity, yield, cost, degree of technical di...

Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism: a cross-sectional study.

Because of the highly penetrant gene mutation and clinical features consistent with idiopathic Parkinson's disease, carriers of the autosomal dominant Ala53Thr (A53T; 209G→A) point mutation in the α-synuclein (SNCA) gene are an ideal population to study the premotor phase and evolution of Parkinson's pathology. Given the known neurochemical changes in the serotonergic system and their associati...

Serotonergic pathology and Braak's staging hypothesis in Parkinson's disease.

Loss of nuclear localization of thyroid transcription factor 1 and adverse outcomes in papillary thyroid Cancer.

Function of the thyroid follicular cell depends on nuclear expression of thyroid transcription factor 1 (TTF1). Regulation of this key protein regulating iodide transport is not well known but its loss is linked to the most lethal of thyroid malignancies. We examined TTF1 nuclear expression in the context of adverse pathological features, disease recurrence, and BRAF status in papillary thyroid ca...

Expediting Drug Development for Pediatric Inflammatory Bowel Disease: A Workshop to Identify Barriers and Move Forward.

Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway.

Increasing evidence indicates that in response to environmental changes, macrophages can dynamically change into two main functional phenotypes, namely M1 and M2. Depending on these different phenotypes, macrophages can produce either pro-inflammatory or anti-inflammatoryfactors which may affect the outcome of inflammation. Mastering the switching of M1/M2 phenotypes may provide therapeutic approa...

Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain.

Osteoarthritis (OA) is the most common form of degenerative arthropathy, and the primary symptom is chronic joint pain. Dehydroepiandrosterone (DHEA) exerts a chondroprotective effect against OA and has been reported to have potent structure-modifying effects on osteoarthritic cartilage, thereby attenuating disease progression. However, the ability of DHEA to modulate OA-related pain has not yet b...

Close encounters between Trypanosoma cruzi and the host mammalian cell: Lessons from genome-wide expression studies.

Trypanosoma cruzi is the etiologic agent of Chagas disease, a life-threatening disease that affects different tissues. Within its mammalian host, T. cruzi develops molecular strategies for successful invasion of different cell types and adaptation to the intracellular environment. Conversely, the host cell responds to the infection by activating intracellular pathways to control parasite replicati...

Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes.

Metabolic syndrome (MetS) describes a cluster of cardio-metabolic factors that predispose to type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). While 35% of Americans suffer from this disorder, the specific pathways related to this disease are largely underexplored. The prevailing consensus is that inflammatory pathways contribute to the pathogenesis of this diseas...

PD-1 blockade with nivolumab controlled Epstein-Barr virus infection and associated hemophagocytic lymphohistiocytosis: a case report.

EBV infection has been associated with a remarkable diverse range of disease and also is a crucial trigger of hemophagocytic lymphohistiocytosis (HLH), which possesses a high mortality rate. According to literature review, 2004 regimen of HLH based on etoposide combined with dexamethasone is main strategy, while the prognosis is poor. Currently, there is no effective treatment strategy about EBV i...

Identification and characterization of hematopoietic stem cell transplant candidates in a sickle cell disease cohort.

Sickle cell disease (SCD) is associated with significant morbidity and allogeneic hematopoietic stem cell transplantation (HSCT) remains the primary curative treatment. Recently, the Brazilian Ministry of Health released a regulation to require the publically funded healthcare system pay for HSCT for SCD patients with defined indications. We used an existing 2794-member SCD cohort established duri...

A novel simplified method of generating cytomegalovirus-specific cytokine-induced killer cells of high specificity and superior potency with GMP compliance.

We describe a method of rendering polyclonal cytokine-induced killer cells (CIK) specific against cytomegalovirus (CMV), focusing on GMP compliance. Peripheral blood mononuclear cells (PBMNC) are stimulated with pooled CMV peptides pp65 and IE-1 for 16-24 h and the reactive T cell subset which up-regulate CD137 is further co-stimulated with anti-CD137, followed by expansion in G-Rex flasks under...

New pathologic mechanisms in nucleotide repeat expansion disorders.

Tandem microsatellite repeats are common throughout the human genome and intrinsically unstable, exhibiting expansions and contractions both somatically and across generations. Instability in a small subset of these repeats are currently linked to human disease, although recent findings suggest more disease-causing repeats await discovery. These nucleotide repeat expansion disorders (NREDs) primar...

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia.

Tau cleavage by different proteolytic enzymes generates short, aggregation-prone fragments that have been implicated in the pathogenesis of Alzheimer's disease (AD). Asparagine endopeptidase (AEP) activity in particular has been associated with tau dysfunction and aggregation, and the activity of the protease is increased in both aging and AD. Using a mass spectrometry approach, we identified a no...

Loneliness and its correlates amongst elderly attending non-communicable disease rural clinic attached to a tertiary care centre of North India.

Psychological and sociological factors like loneliness have a noteworthy influence on the aging. Very less is known about loneliness amongst the elderly populations living with various Non-communicable diseases.

A methodology for generating four-dimensional arterial spin labeling MR angiography virtual phantoms.

Four-dimensional arterial spin labeling magnetic resonance angiography (4D ASL MRA) is a non-invasive medical imaging modality that can be used for anatomical and hemodynamic analysis of the cerebrovascular system. However, it generates a considerable amount of data, which is tedious to analyze visually. As an alternative, medical image processing methods can be used to process the data and presen...

CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.

Atherosclerosis is an inflammatory cardiovascular disorder characterized by accumulation of lipid-loaded macrophages in the intima. Prolonged accumulation leads to apoptosis of macrophages and eventually to progression of lesion development. Prevention of macrophage accumulation within the intima has been shown to reduce lesion formation. Since CD13 mediates trafficking of macrophages to sites of ...

Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.

To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of chalcone-O-carbamate derivatives was designed and synthesized based on the multitarget-directed ligands strategy. The in vitro biological activities were evaluated including AChE/BChE inhibition, MAO-A/MAO-B inhibition, antioxidant activities, Aβ aggregation inhibition, metal-chelating properties and ne...

Characterization of antibody response in patients with acute and chronic chikungunya virus disease.

Chikungunya virus (CHIKV) is a re-emerging arbovirus capable of causing chronic arthralgia, which can last for months to years. Although neutralizing antibodies have been shown to be important for viral clearance, is it not clear whether the quantitative and qualitative nature of antibodies play a role in progression to chronic disease.

Cancer risk in patients with Parkinson's disease in South Korea: A nationwide, population-based cohort study.

The association between Parkinson's disease (PD) and cancer development is controversial, especially in Asia. Therefore, we conducted a nationwide population-based cohort study to assess the overall cancer risk and risk for specific cancers in patients with PD in Korea.

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