Pharmacy Research

09:49 EDT 19th August 2018 | BioPortfolio

Design, synthesis and evaluation of novel diphenyl ether derivatives against drug susceptible and resistant strains of Mycobacterium tuberculosis.

In our efforts to develop druggable diphenyl ethers as potential antitubercular agents, a series of novel diphenyl ether derivatives (5a-f, 6a-f) were designed and synthesized. The representative compounds showed promising in vitro activity against drug susceptible, isoniazid resistant and multi drug resistant strains of Mycobacterium tuberculosis with MIC values of 1.56 μg/mL (6b), 6.25 μg/mL (...

Microbial Biotransformation - An Important Tool for the Study of Drug Metabolism.

1. Metabolite identification is an integral part of both preclinical and clinical drug discovery and development. Synthesis of drug metabolites is often required to support definitive identification, preclinical safety studies and clinical trials. 2. Here we describe the use of microbial biotransformation as a tool to produce drug metabolites, complementing traditional chemical synthesis and other...

Acceptability of Injectable and On-Demand Pre-Exposure Prophylaxis Among an Online Sample of Young Men Who Have Sex with Men in California.

Pre-exposure prophylaxis (PrEP) is an effective strategy to prevent HIV. However, low uptake of daily oral PrEP since Food and Drug Administration approval and low medication adherence among users have stimulated the investigation of other modalities for delivery, such as injectable PrEP and on-demand PrEP. The objective of this study was to determine the demographic and behavioral predictors of w...

Impact of Oral Anticancer Medication From a Family Caregiver Perspective.

To describe how family caregivers of patients receiving oral anticancer medication (OAM) may affect family caregivers' lives and determine what support caregivers need to manage OAM in the home successfully.

Impact of transporters and enzymes from blood-cerebrospinal fluid barrier and brain parenchyma on CNS drug uptake.

In parallel with the blood-brain barrier (BBB), transporters and enzymes on the blood-cerebrospinal fluid barrier (BCSFB) serve as the first barrier for drug brain uptake. In addition, their expressions on the brain parenchyma are considered as the secondary barrier for central nervous system (CNS) drug delivery. Currently, a lack of information on transporters and enzymes expressed on both BCSFB ...

Fighting Kinase Drug Resistance with Caspase Activators.

Kinase inhibitors are effective cancer therapies. Unfortunately, drug resistance emerges in response to kinase inhibition leading to loss of drug efficacy. In this issue of Cell Chemical Biology, Peh et al. (2018) demonstrate that caspase activators effectively delay onset of resistance to kinase inhibitors and are excellent co-therapeutics for a number of tumor types.

Influence of hippocampal low-frequency stimulation on GABAR α1, ICER and BNDF expression level in brain tissues of Amygdala-Kindled drug-resistant temporal lobe epileptic rats.

This study investigated the therapeutic effect of hippocampal low-frequency stimulation (Hip-LFS) and its influence on the typeA γ-aminobutyricacidreceptor α1 subunit (GABAR α1 subunit), inducible cAMP early repressor (ICER) and brain-derived neurotrophic factors (BNDF). The model of epilepsy was induced by chronic electrical stimulation in amygdala. Drug-resistant and drug-sensitive epileptic ...

Challenges and innovations of delivering medicines to older adults.

Older adults with multimorbidity, polypharmacy, and complex health needs are the major consumer of health care. Ensuring that medicines are used safely, effectively, and delivered efficiently in this population is challenging. In this context, the approach to medicines delivery should seek to overcome some of the difficulties of delivering medicines to older people, and ensure each medication is d...

Risk factors for restenosis after drug-coated balloon angioplasty for complex femoropopliteal arterial occlusive disease.

Currently, there exists limited data on patient outcome following the use of drug-coated balloons to treat complex femoropopliteal arterial occlusive lesions. The aim of the present study was to investigate the outcomes of patient treated with drug-coated balloons (DCB) and to identify predictors of restenosis.

How to improve clinical practice on forced medication in psychiatric practice: Suggestions from the EUNOMIA European multicentre study.

The decision to adopt forced medication in psychiatric care is particularly relevant from a clinical and ethical viewpoint. The European Commission has funded the EUNOMIA study in order to develop European recommendations for good clinical practice on coercive measures, including forced medication.

Psychosocial perspective and suicidal behaviors correlated with adolescent male smoking and illicit drug use.

To assess the prevalence of smoking and drug use among adolescent boys, and to examine adolescents' psychosocial factors, and suicidal behaviors associated with adolescents' substance use.

Seeing, Targeting and Delivering with Upconverting Nanoparticles.

Efficient control over drug release is critical to increasing drug efficacy and avoiding side effects. An ideal drug delivery system would deliver drugs in the right amount, at the right location and at the right time noninvasively. This can be achieved using light-triggered delivery: light is noninvasive, spatially precise and safe if appropriate wavelengths are chosen. However, the use of light-...

Prenatal intent and postpartum receipt of long-acting reversible contraception among women receiving medication-assisted treatment for opioid use disorder.

Many women with opioid use disorder (OUD) do not use highly effective postpartum contraception such as long-acting reversible contraception (LARC). We evaluated factors associated with prenatal intent and postpartum receipt of LARC among women receiving medication-assisted treatment (MAT) for OUD.

Mourning our dead: The impact of Mexico's war on drugs on citizens' depressive symptoms.

Research has shown the substantial impact on mental health for victims of drug-related crime in Mexico, especially individuals who have been heavily exposed to violence. However, the effect of drug-related violence in non-victims has been less studied because causal pathways via indirect violence are more ambiguous. We argue that drug-related violence does have an influence on the mental health of...

Lycorine: A prospective natural lead for anticancer drug discovery.

Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid with immense therapeutic potential. Lycorine is active in a very low concentration and with high specificity against a number of cancers both in vivo and in vitro and against various drug-resistant cancer cells. This review summarized the therapeutic effect and the anticancer mechanisms of lycorine. At the ...

Modelling opportunity: An examination of quadratic effects of adolescent Venezuelan substance use.

Numerous studies have found a linear relationship between an exposure opportunity and age of first drug use. This study further tests this relationship by exploring whether a quadratic exposure opportunity best fits the data on age of first use and whether gender moderates this relationship. That is, is there a peak age in which the transition to use occurs for male compared to female adolescents?

Patient safety in nursing care during medication administration.

to evaluate the conformity of care practices of the nursing team during the administration of drugs through central vascular catheter.

Conjugated Polymer Nanoparticles Appending Photo-Responsive Units for Controlled Drug Delivery, Release and Imaging.

Carriers that can afford tunable physical and structural changes are envisioned to address critical issues in controlled drug delivery applications. Herein, we report photo-responsive conjugated polymer nanoparticles (CPNs) functionalized with donor-acceptor Stenhouse adduct (DASA) and folic acid units for controlled drug delivery, release and imaging. Upon visible light (λ = 550 nm) irradiation,...

Synthesis of 1,8-naphthalimide-based probes with fluorescent switch triggered by flufenamic acid.

In this work, we report the synthesis of novel fluorescent molecules, based on 1,8-naphthalimide thio- and amino-derivatives, designed to display an OFF-ON and ON-OFF photoelectron transfer fluorescence switch upon interaction with a proton-donor drug. We have functionalized the new probes to allow easy formation of a covalent link to polymer matrices, for future applications as drug delivery sens...

The molecularly imprinted polymer essentials: curation of anticancer, ophthalmic, and projected gene therapy drug delivery systems.

The development of polymeric materials as drug delivery systems has advanced from systems that rely on classical passive targeting to carriers that can sustain the precisely controlled release of payloads upon physicochemical triggers in desired microenvironment. Molecularly imprinted polymers (MIP), materials designed to capture specific molecules based on their molecular shape and charge distrib...

Evaluation of the adequacy of drug prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort.

Drug prescription is difficult to manage in patients with chronic kidney disease (CKD). We assessed the prevalence and determinants of inappropriate drug prescriptions (whether contraindications or inappropriately high doses) with regard to kidney function in patients with CKD under nephrology care. We also assessed the impact of the equation used to estimate GFR on the prevalence estimates.

Real-World Data Analytics Fit for Regulatory Decision-Making.

Healthcare database analyses (claims, electronic health records) have been identified by various regulatory initiatives, including the 21 Century Cures Act and Prescription Drug User Fee Act ("PDUFA"), as useful supplements to randomized clinical trials to generate evidence on the effectiveness, harm, and value of medical products in routine care. Specific applications include accelerated drug app...

Dual-layer Strengthened Collaborative Topic Regression Modeling for Predicting Drug Sensitivity.

An effective way to facilitate the development of modern oncology precision medicine is the systematical analysis of the known drug sensitivities that have emerged in recent years. Meanwhile, the screening of drug response in cancer cell lines provides an estimable genomic and pharmacological data towards high accuracy prediction. Existing works primarily utilize genomic or functional genomic feat...

Multimorbidity in patients with chronic migraine and medication overuse headache.

Patients with chronic migraine (CM) display a considerable amount of comorbidities, particularly psychiatric and cardiovascular, and the presence of multiple comorbidities, i.e. the so-called multimorbidity, is a risk factor for migraine chronification or maintenance of CM. Our aim is to address the rate and impact of multimorbidity in patients with CM and medication overuse headache (MOH).

Tumor drug penetration measurements could be the neglected piece of the personalized cancer treatment puzzle.

Precision medicine aims to use patient genomic, epigenomic, specific drug dose and other data to define disease patterns that may potentially lead to an improved treatment outcome. Personalized dosing regimens based on tumor drug penetration can play a critical role in this approach. State-of-the-art techniques to measure tumor drug penetration focus on systemic exposure, tissue penetration, cellu...

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