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Pregnancy Category C : Animal reproduction studies have not been conducted with fomepizole. It is also not known whether fomepizole can cause fetal harm when administered to pregnant women or can affect reproduction capacity. Fomepizole should be given to pregnant women only if clearly needed.
Stability : Fomepizole diluted in 0.9% sodium chloride injection or dextrose 5% injection remains stable and sterile for at least 24 hours when stored refrigerated or at room temperature. Fomepizole does not contain preservatives. Therefore, maintain sterile conditions, and after dilution do not use beyond 24 hours.
Solutions showing haziness, particulate matter, precipitate, discoloration, or leakage should not be used.
|DOSE AT THE BEGINNING OF HEMODIALYSIS|
|If <6 hours since last fomepizole dose||If ≥ 6 hours since last fomepizole dose|
|Do not administer dose||Administer next scheduled dose|
|DOSING DURING HEMODIALYSIS|
|Dose every 4 hours|
|DOSING AT THE TIME HEMODIALYSIS IS COMPLETED|
Time between last dose and the end of
|<1 hour||Do not administer dose at the end of
|1-3 hours||Administer 1/2 of next scheduled dose|
|>3 hours||Administer next scheduled dose|
|MAINTENANCE DOSING OFF HEMODIALYSIS|
|Give next scheduled dose 12 hours from last dose administered|
Rx only Sterile Caution: Must be diluted prior to use.
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