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QUADRAMET Prescribing Information QUADRAMET (SAMARIUM SM 153 LEXIDRONAM INJECTION) May 2009                                                              | Quadramet

13:30 EDT 24th July 2014 | BioPortfolio

Note: While we endeavour to keep our records up-to-date one should not rely on these details being accurate without first consulting a professional. Click here to read our full medical disclaimer.

QUADRAMET is a therapeutic agent consisting of radioactive samarium and a tetraphosphonate chelator, ethylenediaminetetramethylenephosphonic acid (EDTMP). QUADRAMET is formulated as a sterile, non-pyrogenic, clear, colorless to light amber isotonic solution of samarium-153 lexidronam for intravenous administration. QUADRAMET does not contain a preservative.

Each milliliter contains 35 mg EDTMP•HO, 5.3 mg Ca [as Ca(OH)], 14.1 mg Na [as NaOH], equivalent to 44 mg Ca/Na EDTMP (anhydrous calc.), 5-46 µg samarium (specific activity of approximately 1.0-11.0 mCi/µg Sm), and 1850 ± 185 MBq (50 ± 5 mCi) of samarium-153 at calibration.

The structural formula of samarium lexidronam pentasodium is:

The ionic formula is Sm [CHN(CHPO )] and the ionic formula weight is 581.1 daltons (pentasodium form, 696).

The pH of the solution is 7.0 to 8.5.

QUADRAMET is supplied frozen in single-dose glass vials containing 3 mL with 5550 MBq (150 mCi) of samarium-153 at calibration.

IMAGE quadramet-1.jpg

Samarium-153 is produced in high yield and purity by neutron irradiation of isotopically enriched samarium Sm 152 oxide (SmO). It emits both medium-energy beta particles and a gamma photon, and has a physical half-life of 46.3 hours (1.93 days). Samarium-153 has average and maximum beta particle ranges in water of 0.5 mm and 3.0 mm, respectively. The primary radiation emissions of samarium-153 are shown in Table 1.

TABLE 1 - SAMARIUM-153 PRINCIPAL RADIATION EMISSION DATA
  *Maximum energies are listed for the beta emissions, the average beta particle energy is 233 keV.
   Radiation
Energy
(keV)*
 Abundance
 Beta  640  30%
 Beta  710  50%
 Beta  810  20%
 Gamma  103  29%

The specific gamma-ray constant for samarium-153 is 0.46 R/mCi-hr at 1 cm (1.24x10 mSv/MBq- hr at 1 Meter). The half-value thickness of lead (Pb) for samarium-153 is approximately 0.10 mm. The use of 1 mm of lead will decrease the external radiation exposure by a factor of approximately 1,000. QUADRAMET should be stored in a lead-shielded container and frozen until use.

Radioactive decay factors to be applied to the stated value for radioactive concentration at calibration are given in Table 2. All radioactivity is calibrated to the reference date and time on the vial.

TABLE 2 - SAMARIUM-153 PHYSICAL DECAY CHART, HALF-LIFE 46.3 HOURS(1.93 DAYS)
  *Time = hours before (-) or after (+) calibration
 Time
(hour)*
 Factor  Time
(hour)*
 Factor
 -56.0  2.31  +1.0  0.99
 -48.0  2.05  +2.0  0.97
 -36.0  1.71  +3.0  0.96
 -24.0  1.43  +4.0  0.94
 -20.0  1.35  +6.0  0.91
 -16.0  1.27  +8.0  0.89
 -12.0  1.20  +12.0  0.84
 -8.0  1.13  +16.0  0.80
 -6.0  1.09  +20.0  0.74
 -4.0  1.06  +24.0  0.70
 -3.0  1.05  +36.0  0.58
 -2.0  1.03  +48.0  0.49
 -1.0  1.02  +56.0  0.43

QUADRAMET (samarium Sm-153 EDTMP) has an affinity for bone and concentrates in areas of bone turnover in association with hydroxyapatite. In clinical studies employing planar imaging techniques, more QUADRAMET accumulates in osteoblastic lesions than in normal bone with a lesion-to-normal bone ratio of approximately 5. The mechanism of action of QUADRAMET in relieving the pain of bone metastases is not known.

Human protein binding has not been studied; however, in dog, rat and bovine studies, less than 0.5% of samarium-153 EDTMP is bound to protein. At physiologic pH, >90% of the complex is present as Sm[EDTMP], and <10% as SmH[EDTMP]. The octanol/ water partition coefficient is <10.

The greater the number of metastatic lesions, the more skeletal uptake of Sm-153 radioactivity. The relationship between skeletal uptake and the size of the metastatic lesions has not been studied. The total skeletal uptake of radioactivity was 65.5%± 15.5% of the injected dose in 453 patients with metastatic lesions from a variety of primary malignancies. In a study of 22 patients with a wide range in the number of metastatic sites, the % of the injected dose (% ID) taken up by bone ranged from 56.3% in a patient with 5 metastatic lesions to 76.7% in a patient with 52 metastatic lesions. If the number of metastatic lesions is fixed, over the range 0.1 to 3.0 mCi/kg, the % ID taken up by bone is the same regardless of the dose.

The complex formed by samarium and EDTMP is excreted as an intact, single species that consists of one atom of the Sm-153 and one molecule of the EDTMP, as shown by an analysis of urine samples from patients (n=5) administered samarium Sm-153 EDTMP. Metabolic products of samarium Sm-153 EDTMP were not detected in humans.

For QUADRAMET, calculations of the % ID detected in the whole body, urine and blood were corrected for radionuclide decay. The clearance of activity through the urine is expressed as the cumulated activity excreted. The whole body retention is the simple reciprocal of the cumulated urine activity. (See Skeletal Uptake Section).

Blood: Clearance of radioactivity from the blood demonstrated biexponential kinetics after intravenous injection in 19 patients (10 men, 9 women) with a variety of primary cancers that were metastatic to bone. Over the first 30 minutes, the radioactivity (mean ± SD) in the blood decreased to 15% (±8%) of the injected dose with a t 1/2 of 5.5 min (±1.1 min). After 30 minutes, the radioactivity cleared from the blood more slowly with a t1/2 of 65.4 min (± 9.6 min). Less than 1% of the dose injected remained in the blood 5 hr after injection.

Urine: Samarium Sm-153 EDTMP radioactivity was excreted in the urine after intravenous injection. During the first 6 hours, 34.5% (±15.5%) was excreted. Overall, the greater the number of metastatic lesions, the less radioactivity was excreted.

Gender did not affect the samarium Sm-153 EDTMP blood pharmacokinetics, the cumulative % of radioactivity excreted in urine, or the % radioactivity retained in the skeleton when the number of metastatic lesions is taken into account.

Elderly: The pharmacokinetics of samarium Sm-153 EDTMP did not change with age as seen from comparison of values from people in the age range of 22 to 64 compared to the range 65 to 86 years.

Hepatic Insufficiency: Samarium Sm-153 EDTMP scintiscans in 5 patients with metastatic bone disease did not reveal accumulation of activity in the liver or the intestine; this suggests that hepatobiliary excretion did not occur.

Renal Insufficiency: Patients with renal insufficiency have not been studied.

Drug-drug interaction studies have not been studied.

The beta particle of Sm-EDTMP travels a maximum of 3.0 mm in soft tissue and 1.7 mm in bone. In clinical trials of 78 patients with metastatic bone lesions who had 13 specific bone scan sites evaluated, the presence or absence of Sm-EDTMP uptake is similar to the presence or absence of Tc diphosphonate uptake (range 67 to 96% agreement depending upon the blinded reader and the site of the body). Whether the amount of Sm-EDTMP uptake varies with the size of the lesion or to the presence of osteolytic components has not been studied. The clinical benefit of Sm-153-EDTMP in patients with osteolytic lesions is not known. The relationship of different tumor cell types to clinical response has not been studied.

Overall QUADRAMET was evaluated in 580 patients (see Adverse Events Section for demographic description). Of these patients, 270 (244 men, 26 women) were studied in two randomized, blinded, placebo controlled clinical trials. These patients had a mean age of 67, and a range 22 to 87 years. Eligible patients had painful metastatic bone lesions that had failed other treatments, had at least a 6 month expected survival and had a positive radionuclide bone scan. Routine x-rays to evaluate the metastatic lesions were not part of the protocol.

In study A, 118 patients were randomized to receive 0.5 mCi/kg QUADRAMET, 1.0 mCi/kg QUADRAMET, or a placebo intravenous injection. In study B, 152 patients were randomized to receive either 1.0 mCi/kg QUADRAMET or a placebo intravenous injection. Both studies were double blind over a 4 week period. Patients scored their daily pain intensity on a visual analogue scale rated from 0 (no or low pain) to 10 (excruciating pain). The area under the pain curve (AUPC) was obtained by integrating the daily pain scores by week. Opioid analgesic use was recorded daily and averaged over each week and expressed in oral morphine milligram equivalents.

Of the 270 patients studied, 232 (86%) had prostate cancer and 38 (14%) had other primary cancers. In study A, 80 (68%) of the patients had prostate cancer and 38 (32%) had a variety of other primary tumors. In study B, all (100%) patients had prostate cancer.

The results of the patients’ AUPC scores are shown in Table 3. In both trials for each of the 4 weeks of study, the mean AUPC scores decreased in patients who received QUADRAMET (1.0 mCi/kg). In study A, pain (the AUPC) decrease from baseline was significantly different in QUADRAMET 1.0 mCi/kg and placebo groups at weeks 3 and 4. In study B, pain (the AUPC) decrease from baseline was significantly different in QUADRAMET 1.0 mCi/kg and placebo groups at weeks 2, 3 and 4.

In the two clinical trials, the patient use of analgesics differed. In Study A, the patients did not receive specific instructions on analgesic reduction. In Study B, patients were encouraged to adjust their pain medication as needed. As shown in Table 4, the morphine equivalent analgesic use in study A generally increased from baseline in both the QUADRAMET and placebo treatment groups; however, the difference between the QUADRAMET and placebo group change from baseline is not statistically significant. In study B, the placebo treated patients increased their use of opioid analgesics, while the QUADRAMET treated patients decreased their use of opioid analgesics.

In both studies, the numbers of patients who experienced any decrease in AUPC score without any increase in analgesic use at weeks 3 and 4 were also evaluated. In study A, this occurred in 20/37 (54%) of the patients who received QUADRAMET 1.0 mCi/kg and 9/36 (25%) of the placebo treated patients. In study B, this occurred in 48/100 (48%) of the QUADRAMET treated patients and 11/51 (22%) of the placebo treated patients.

Table 3: COMPARISON OF WEEKLY PAIN SCORES (a)AFTER QUADRAMET® 1.0mCi/kg or PLACEBO IV [Intent to Treat]
   STUDY A (n = 73) (b)  STUDY B (n = 150) (c)
 WEEK      Placebo     N=36      1.0 mCi/kg     N=37      Placebo     N=50      1.0 mCi/kg     N=100
 Baseline      26.5 (11.8)      28.7 (12.3)      28.5 (14.1)      28.1 (12.9)
 1      26.1 (10.3)      27.6 (14.1)      27.9 (14.6)      25.8 (13.1)
 2      24.4 (10.4)      23.8 (13.7)      28.1 (15.4)      20.6 (13.9)*
 3      24.3 (11.0)      20.5 (11.5)*      25.8 (16.1)      20.1 (13.3)*
 4      24.7 (12.1)      18.8 (10.8)*      24.7 (15.3)      19.9 (13.7)*
Table 4: COMPARISON OF WEEKLY MEAN ANALGESIC USE (a) BETWEEN QUADRAMET® 1.0 mCi/kg AND PLACEBO GROUPS [Intent to Treat]
   STUDY A (n = 73) (b)  STUDY B (n = 150) (c)
 WEEK      Placebo     N=36      1.0 mCi/kg     N=37      Placebo     N=50      1.0 mCi/kg     N=100
 Baseline      93.5 (154.0)(a)      127.1 (189.9)      78.4 (83.1)      96.5 (166.6)
 1      106.8 (173.8)      125.7 (192.6)      84.5 (91.1)      93.5 (165.5)
 2      127.1 (238.4)      144.8 (276.7)      85.6 (90.9)      82.9 (122.9)
 3      133.9 (254.0)      146.6 (278.2)      100.1 (119.4)      79.6 (131.2)*
 4      135.6 (222.0)      135.1 (274.0)      106.3 (161.0)      76.8 (132.3)*

QUADRAMET is indicated for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan.

QUADRAMET is contraindicated in patients who have known hypersensitivity to EDTMP or similar phosphonate compounds.

QUADRAMET causes bone marrow suppression. In clinical trials, white blood cell counts and platelet counts decreased to a nadir of approximately 40% to 50% of baseline in 123 (95%) of patients within 3 to 5 weeks after QUADRAMET, and tended to return to pretreatment levels by 8 weeks. The grade of marrow toxicity is shown in Table 5 below.

Before QUADRAMET is administered, consideration should be given to the patient’s current clinical and hematologic status and bone marrow response history to treatment with myelotoxic agents. Metastatic prostate and other cancers can be associated with disseminated intravascular coagulation (DIC); caution should be exercised in treating cancer patients whose platelet counts are falling or who have other clinical or laboratory findings suggesting DIC. Because of the unknown potential for additive effects on bone marrow, QUADRAMET should not be given concurrently with chemotherapy or external beam radiation therapy unless the clinical benefits outweigh the risks. Use of QUADRAMET in patients with evidence of compromised bone marrow reserve from previous therapy or disease involvement is not recommended unless the potential benefits of the treatment outweigh the risks. Blood counts should be monitored weekly for at least 8 weeks, or until recovery of adequate bone marrow function.

Table 5: NUMBER AND PERCENT OF PATIENTS WHO EXPERIENCED MARROW TOXICITY IN CLINICAL TRIALS OF QUADRAMET®
   Hemoglobin  Leucocytes  Platelets
 Toxicity Grade*      Placebo     N=85      1.0 mCi/kg     N=185      Placebo     N=85      1.0 mCi/kg     N=184      Placebo     N=85      1.0 mCi/kg     N=185
 0-2      78 (92%)      162 (88%)      85 (100%)      169 (92%)      85 (100%)      173 (94%)
 3      6 (7%)      20 (11%)      0 (0%)      15 (8%)      0 (0%)      10 (5%)
 4      1 (1%)      3 (2%)      0 (0%)      0 (0%)      0 (0%)      2 (1%)

As with other radiopharmaceutical drugs, QUADRAMET can cause fetal harm when administered to a pregnant woman. Adequate and well controlled studies have not been conducted in animals or pregnant women. Women of child-bearing age should have a negative pregnancy test before administration of QUADRAMET. If this drug is used during pregnancy, or if a patient becomes pregnant after taking this drug, the patient should be apprised of the potential hazard to the fetus. Women of child-bearing potential should be advised to avoid becoming pregnant soon after receiving QUADRAMET. Men and women patients should be advised to use an effective method of contraception after the administration of QUADRAMET.

EDTMP is a chelating agent. Although the chelating effects have not been evaluated thoroughly in humans, dogs that received non-radioactive samarium EDTMP (6 times the human dose based on body weight, 3 times based on surface area) developed a variety of electrocardiographic (ECG) changes (with or without the presence of hypocalcemia). The causal relationship between the hypocalcemia and ECG changes has not been studied. Whether QUADRAMET causes electrocardiographic changes or arrhythmias in humans has not been studied. Caution and appropriate monitoring should be given when administering QUADRAMET to patients (See Laboratory Tests).

Because concomitant hydration is recommended to promote the urinary excretion of QUADRAMET, appropriate monitoring and consideration of additional supportive treatment should be used in patients with a history of congestive heart failure or renal insufficiency.

This drug should be used with caution in patients with compromised bone marrow reserves. See Warnings.

Skeletal: Spinal cord compression frequently occurs in patients with known metastases to the cervical, thoracic or lumbar spine. In clinical studies of QUADRAMET, spinal cord compression was reported in 7% of patients who received placebo and in 8.3% of patients who received 1.0 mCi/kg QUADRAMET. QUADRAMET is not indicated for treatment of spinal cord compression. QUADRAMET administration for pain relief of metastatic bone cancer does not prevent the development of spinal cord compression. When there is a clinical suspicion of spinal cord compression, appropriate diagnostic and therapeutic measures must be taken immediately to avoid permanent disability.

Radiopharmaceutical agents should be used only by physicians who are qualified by training and experience in the safe use and handling of radionuclides and whose experience and training have been approved by the appropriate government agency authorized to license the use of radionuclides.

QUADRAMET, like other radioactive drugs, must be handled with care, and appropriate safety measures must be taken to minimize radiation exposure of clinical personnel and others in the patient environment.

Special precautions, such as bladder catheterization, should be taken with incontinent patients to minimize the risk of radioactive contamination of clothing, bed linen, and the patient's environment. Urinary excretion of radioactivity occurs over about 12 hours (with 35% occurring during the first 6 hours). Studies have not been done on the use of QUADRAMET in patients with renal impairment.

Patients who receive QUADRAMET should be advised that for several hours following administration, radioactivity will be present in excreted urine. To help protect themselves and others in their environment, precautions need to be taken for 12 hours following administration. Whenever possible, a toilet should be used, rather than a urinal, and the toilet should be flushed several times after each use. Spilled urine should be cleaned up completely and patients should wash their hands thoroughly. If blood or urine gets onto clothing, the clothing should be washed separately, or stored for 1-2 weeks to allow for decay of the Sm-153.

Some patients have reported a transient increase in bone pain shortly after injection (flare reaction). This is usually mild and self-limiting and occurs within 72 hours of injection. Such reactions are usually responsive to analgesics.

Patients who respond to QUADRAMET might begin to notice the onset of pain relief one week after QUADRAMET. Maximal pain relief generally occurs at 3-4 weeks after injection of QUADRAMET. Patients who experience a reduction in pain may be encouraged to decrease their use of opioid analgesics.

Because of the potential for bone marrow suppression, beginning 2 weeks after QUADRAMET administration, blood counts should be monitored weekly for at least 8 weeks, or until recovery of adequate bone marrow function.

In a subset of 31 patients who had serum calcium monitored during the first 2 hours after QUADRAMET infusion, a clear pattern of calcium change was not identified. However, 10 (32%) patients had at least one serum calcium level that was below normal (7.16 to 8.28). The extent to which samarium-153-EDTMP is related to this hypocalcemia is not known. Caution should be exercised when administering QUADRAMET to patients at risk for developing hypocalcemia.

The potential for additive bone marrow toxicity of QUADRAMET with chemotherapy or external beam radiation has not been studied. QUADRAMET should not be given concurrently with chemotherapy or external beam radiation therapy unless the benefit outweighs the risks. QUADRAMET should not be given after either of these treatments until there has been time for adequate marrow recovery. (See Warnings Section).

Carcinogenesis in humans given EDTMP, in QUADRAMET, is not likely. Osteosarcomas occurred in a 2-year toxicity/carcinogenicity study of EDTMP administered by gastric intubation to Sprague-Dawley rats, in male rats at 50 mg/kg/day and in male and female rats at 150 mg/kg/day (the dosage was increased to 333 mg/kg/day on day 329 of treatment). Osteosarcomas were not reported in a published chronic dietary study of up to 130 weeks of EDTMP in Fisher 344 rats, at dietary doses up to 100 mg/kg/day (not the maximum tolerated dose). However, at study termination in female Fisher 344 rats, this dose was associated with statistically significantly higher rate of pancreatic islet-cell adenomas and carcinomas.

The results of the following genotoxicity assays with non-radioactive samarium- EDTMP were negative: Salmonella reverse mutation (AMES) assay, unscheduled DNA synthesis in rat liver primary cell culture, chromosomal aberration assay in rat lymphocytes, CHO/HGPRT forward mutation assay, and mouse bone marrow micronucleus test.

Studies have not been performed to assess the effect of QUADRAMET on fertility.

Pregnancy Category D. See Warnings Section.

It is not known whether QUADRAMET is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from QUADRAMET, a decision should be made whether to continue nursing or to administer the drug. If QUADRAMET is administered, formula feedings should be substituted for breast feedings.

Safety and effectiveness in pediatric patients below the age of 16 years have not been established.

Adverse events were evaluated in a total of 580 patients who received QUADRAMET in clinical trials. Of the 580 patients, there were 472 men and 108 women with a mean age of 66 (range 20 to 87).

Of these patients, 472 (81%) had at least one adverse event. In a subgroup of 399 patients who received QUADRAMET 1.0 mCi/kg, there were 23 deaths and 46 serious adverse events. The deaths occurred an average of 67 days (9 to 130) after QUADRAMET. Serious events occurred an average of 46 days (1 - 118) after QUADRAMET. Although most of the patient deaths and serious adverse events appear to be related to the underlying disease, the relationship of end stage disease, marrow invasion by cancer cells, previous myelotoxic treatment and QUADRAMET toxicity can not be easily distinguished. In clinical studies, two patients with rapidly progressive prostate cancer developed thrombocytopenia and died 4 weeks after receiving QUADRAMET. One of the patients showed evidence of disseminated intravascular coagulation (DIC); the other patient experienced a fatal cerebrovascular accident, with a suspicion of DIC. The relationship of the DIC to the bone marrow suppressive effect of Samarium is not known. Marrow toxicity occurred in 277 (48%) patients (See Warnings section).

In controlled studies, 7% of patients receiving 1.0 mCi/kg QUADRAMET (as compared to 6% of patients receiving placebo) reported a transient increase in bone pain shortly after injection (flare reaction). This was usually mild, self-limiting, and responded to analgesics.

The most common adverse events observed in controlled clinical studies of QUADRAMET, are given in Table 6.    

In an additional 200 patients who received QUADRAMET in uncontrolled clinical trials, adverse events that were reported at a rate of ≥ 1.0% were similar except for 9 (4.5%) patients who had agranulocytosis. Other selected adverse events that were reported in <1% of the patients who received QUADRAMET 1.0 mCi/kg in any clinical trial include: alopecia, angina, congestive heart failure, sinus bradycardia, and vasodilation.

TABLE 6 SELECTED ADVERSE EVENTS REPORTED IN ≥ 1.0 % OF PEOPLE WHO RECEIVED QUADRAMET® OR PLACEBO IN CONTROLLED CLINICAL TRIALS
 ADVERSE EVENT      Placebo

    N = 90
     QUADRAMET®
    1.0 mCi/kg
    N = 199
 # Patients with Any Adverse Event      72 (80%)      169 (85%)
  Body As A Whole      56 (62%)      100 (50%)
 Pain Flare Reaction      5 (5.6%)      14 (7.0%)
  Cardiovascular      19 (21%)      32 (16%)
 Arrhythmias      2 (2.2%)      10 (5.0%)
 Chest Pain      4 (4.4%)      8 (4.0%)
 Hypertension      0      6 (3.0%)
 Hypotension      2 (2.2%)      4 (2.0%)
  Digestive      44 (49%)      82 (41%)
 Abdominal Pain      7 (7.8%)      12 (6.0%)
 Diarrhea      3 (3.3%)      12 (6.0%)
 Nausea &/or Vomiting      37 (41.1%)      65 (32.7%)
  Hematologic & Lymphatic      12 (13%)      54 (27%)
 Coagulation Disorder      0      3 (1.5%)
 Hemoglobin Decreased      21 (23.3%)      81 (40.7%)
 Leukopenia      6 (6.7%)      118(59.3%)
 Lymphadenopathy      0      4 (2.0%)
 Thrombocytopenia      8 (8.9%)      138(69.3%)
  Any Bleeding Manifestations*      8 (8.9%)      32 (16.1%)
 Ecchymosis      1 (1.1%)      3 (3.0%)
 Epistaxis      1 (1.1%)      4 (2.0%)
 Hematuria      3 (3.3%)      10 (5%)
  Infection      10 (11.1%)      34 (17.1%)
 Fever and/or Chills      10 (11.1%)      17 (8.5%)
 Infection, Not Specified      4 (4.4%)      14 (7.0%)
 Oral Moniliasis      1 (1.1%)      4 (2.0%)
 Pneumonia      1 (1.1%)      3 (1.5%)
  Musculoskeletal      28 (31%)      55 (27%)
 Myasthenia      8 (8.9%)      13 (6.5%)
 Pathologic Fracture      2 (2.2%)      5 (2.5%)
  Nervous      39 (43%)      59 (30%)
 Dizziness      1 (1.1%)      8 (4.0%)
 Paresthesia      7 (7.8%)      4 (2.0%)
 Spinal Cord Compression      5 (5.5%)      13 (6.5%)
 Cerebrovascular Accident/Stroke      0      2 (1.0%)

Manufacturer

EUSA Pharma (USA), Inc.

Active Ingredients

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Drugs and Medications [1 Associated Drugs and Medications listed on BioPortfolio]

Quadramet prescribing information quadramet(samarium sm 153 lexidronam injection513145-0903 september 2003                                                                           [Cytogen Corporation]

QUADRAMET Prescribing Information QUADRAMET(SAMARIUM SM 153 LEXIDRONAM INJECTION513145-0903 September 2003                                               ...

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