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These highlights do not include all the information needed to use DIFFERIN safely and effectively. See full prescribing information for DIFFERIN (adapalene) Gel, 0.3% DIFFERIN (adapalene) Gel, 0.3% For topical use only Initial U.S. Approval: 1996 | DIFFERIN [Galderma Laboratories, L.P.] | BioPortfolio

12:27 EST 27th January 2019 | BioPortfolio
Note: While we endeavour to keep our records up-to-date one should not rely on these details being accurate without first consulting a professional. Click here to read our full medical disclaimer.

DIFFERIN Gel, 0.3% is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.

Apply a thin film of DIFFERIN Gel, 0.3% to the entire face and any other affected areas of the skin once daily in the evening, after washing gently with a non-medicated soap.  Avoid application to the areas of skin around eyes, lips, and mucous membranes.  A mild transitory sensation of warmth or slight stinging may occur shortly after the application of DIFFERIN Gel, 0.3%.  Patients should be instructed to minimize sun exposure.  Patients may be instructed to use moisturizers for relief of dry skin or irritation.

If therapeutic results are not noticed after 12 weeks of treatment, therapy should be re-evaluated.

For topical use only.  Not for ophthalmic, oral or intravaginal use.

Each gram of DIFFERIN Gel, 0.3% contains 3 mg adapalene in an off-white aqueous gel.

DIFFERIN Gel, 0.3% should not be administered to individuals who are hypersensitive to adapalene or any of the components in the gel vehicle.

Exposure to sunlight, including sunlamps, should be minimized during use of DIFFERIN Gel, 0.3%.  Patients who normally experience high levels of sun exposure, and those with inherent sensitivity to sun, should be warned to exercise caution.  Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.  Weather extremes, such as wind or cold, also may be irritating to patients under treatment with DIFFERIN Gel, 0.3%.

Certain cutaneous signs and symptoms of treatment such as erythema, scaling, dryness, and stinging/burning were reported with use of DIFFERIN Gel, 0.3%.  These were most likely to occur during the first four weeks of treatment, were mostly mild to moderate in intensity, and usually lessened with continued use of the medication.  Depending upon the severity of these side effects, patients should be instructed to either use a moisturizer, reduce the frequency of application of DIFFERIN Gel, 0.3% or discontinue use.

Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. The product should not be applied to cuts, abrasions, eczematous or sunburned skin.  As with other retinoids, use of "waxing" as a depilatory method should be avoided on skin treated with adapalene.

As DIFFERIN Gel has the potential to induce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution.

Reactions characterized by symptoms such as pruritus, face edema, eyelid edema, and lip swelling, requiring medical treatment have been reported during postmarketing use of adapalene. A patient should stop using DIFFERIN Gel, 0.3% and consult a doctor if experiencing allergic or anaphylactoid/anaphylactic reactions (e.g., skin rash, pruritus, hives, chest pain, edema, and shortness of breath) during treatment.

Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In the multi-center, controlled clinical trial, signs and symptoms of local cutaneous irritation were monitored in 258 acne patients who used DIFFERIN Gel, 0.3% once daily for 12 weeks. Of the patients who experienced cutaneous irritation (erythema, scaling, dryness, and/or burning/stinging), the majority of cases were mild to moderate in severity, occurred early in treatment and decreased thereafter. The incidence of local cutaneous irritation with DIFFERIN Gel, 0.3% from the controlled clinical study is provided in the following table:

* Total number of subjects with local cutaneous data for at least one post-Baseline evaluation

* Selected adverse reactions defined by investigator as Possibly, Probably or Definitely Related

Related adverse reactions from the controlled clinical trial that occurred in greater than 1% of patients who used DIFFERIN Gel, 0.3% once daily included: dry skin (14.0%), skin discomfort (5.8%), pruritus (1.9%), desquamation (1.6%), and sunburn (1.2%). The following selected adverse reactions occurred in less than 1% of patients: acne flare, contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.

In a one-year, open-label safety study of 551 patients with acne who received DIFFERIN Gel, 0.3%, the pattern of adverse reactions was similar to the 12-week controlled study.

Table 1: Physician assessed local cutaneous irritation with DIFFERIN Gel
Incidence of Local Cutaneous Irritation with DIFFERIN Gel, 0.3%
from Controlled Clinical Trials
(N = 253*)
Maximum Severity Scores Higher Than Baseline
Mild Moderate Severe
Erythema 66 (26.1%) 33 (13.0%) 1 (0.4%)
Scaling 110 (43.5%) 47 (18.6%) 3 (1.2%)
Dryness 113 (44.7%) 43 (17.0%) 2 (0.8%)
Burning/Stinging 72 (28.5%) 36 (14.2%) 9 (3.6%)
Table 2: Patient reported local cutaneous reactions with DIFFERIN Gel
DIFFERIN (adapalene) Gel, 0.3% Vehicle Gel
N = 258 N = 134
Related* Adverse Reactions
          Dry Skin
          Skin Discomfort
          Desquamation
57 (22.1%)
36 (14%)
15 (5.8%)
4 (1.6%)
6 (4.5%)
2 (1.5%)
0 (0%)
0 (0%)

The following adverse reactions have been identified during post approval use of adapalene: skin irritation, application site pain, face edema, eyelid edema, lip swelling, and angioedema.  Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate the frequency or establish a causal relationship to drug exposure.

7.1 Concomitant Topical Medications

As DIFFERIN Gel, 0.3% has the potential to induce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with DIFFERIN Gel, 0.3%. If these preparations have been used, it is advisable not to start therapy with DIFFERIN Gel, 0.3%, until the effects of such preparations have subsided.

No formal drug-drug interaction studies were conducted with DIFFERIN Gel, 0.3%.

Teratogenic effects.  Pregnancy Category C. Retinoids may cause fetal harm, when administered to pregnant women.  Adapalene has been shown to be teratogenic in rats and rabbits when administered orally (see Animal Data below).  There are no adequate and well-controlled studies in pregnant women.  DIFFERIN Gel, 0.3% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.  The safety and efficacy of DIFFERIN Gel, 0.3% in pregnancy has not been established.

Human Data

In clinical trials involving DIFFERIN Gel, 0.3% in the treatment of acne vulgaris, women of child-bearing potential initiated treatment only after having had a negative pregnancy test and used effective birth control measures during therapy.  However, 6 women treated with DIFFERIN Gel, 0.3% became pregnant.  One patient elected to terminate the pregnancy, two patients delivered healthy babies by normal delivery, two patients delivered prematurely and the babies remained in intensive care until reaching a healthy state and one patient was lost to follow-up.

Animal Data

It is not known whether adapalene is excreted in human milk.  Because many drugs are excreted in human milk, caution should be exercised when DIFFERIN Gel, 0.3% is administered to a nursing woman.

Safety and effectiveness have not been established in pediatric patients below the age of 12.

Clinical studies of DIFFERIN Gel, 0.3% did not include subjects 65 years of age and older to determine whether they respond differently than younger subjects.  Safety and effectiveness in geriatric patients age 65 and above have not been established.

DIFFERIN Gel, 0.3% is intended for topical use only.  If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, scaling, or skin discomfort may occur.  Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of vitamin A.

DIFFERIN (adapalene) Gel, 0.3% contains adapalene 0.3% (3 mg/g) in a topical aqueous gel for use in the treatment of acne vulgaris, consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide.  May contain hydrochloric acid for pH adjustment.

The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid.  It is a white to off-white powder, which is soluble in tetrahydrofuran, very slightly soluble in ethanol, and practically insoluble in water.  The molecular formula is CHO and molecular weight is 412.53.  Adapalene is represented by the following structural formula.

Adapalene binds to specific retinoic acid nuclear receptors but does not bind to cytosolic receptor protein.  Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown.

Clinical pharmacodynamic studies have not been conducted for Differin Gel, 0.3%.

Systemic exposure of adapalene following topical application of DIFFERIN Gel was evaluated in a clinical study. Sixteen acne patients were treated once daily for 10 days with 2 grams of DIFFERIN Gel, 0.3% applied to the face, chest and back, corresponding to approximately 2 mg/cm.  Fifteen patients had quantifiable (LOQ = 0.1 ng/mL) adapalene levels resulting in a mean C of 0.553 ± 0.466 ng/mL on Day 10 of treatment.  The mean AUC was 8.37 ± 8.46 ng.h/mL as determined in 15 of the 16 patients on Day 10.  The terminal apparent half-life, determined in 15 of 16 patients, ranged from 7 to 51 hours, with a mean of 17.2 ± 10.2 hours.  Adapalene was rapidly cleared from plasma and was not detected 72 hours after the last application for all but one subject.  Exposure of potential circulating metabolites of adapalene was not measured.  Excretion of adapalene appears to be primarily by the biliary route.

In another clinical study in patients with moderate to moderately severe acne, DIFFERIN (adapalene) Gel, 0.3% or Adapalene Gel, 0.1% was applied to the face and optionally to the trunk, once daily for 12 weeks.  Seventy-eight (78) patients had plasma adapalene levels evaluated at Weeks 2, 8, and 12.  Of the 209 plasma samples analyzed, adapalene concentrations were below the limit of detection (LOD = 0.15 ng/mL) of the method in all samples but three.  For the three samples, traces of adapalene below the limit of quantification (LOQ = 0.25 ng/mL) of the method were found.  One of these samples was taken at Week 12 from a male patient treated with DIFFERIN Gel, 0.3% who treated the face and the trunk for eight weeks (thereafter, only the face was treated).  The second and third samples were from the Week 2 and 12 visits of a female patient treated with Adapalene Gel, 0.1% who treated only the face for 12 weeks.  In this study, the average daily usage of product was 1 g/day.

Carcinogenicity studies with adapalene have been conducted in mice at topical doses of 0.4, 1.3, and 4.0 mg/kg/day, and in rats at oral doses of 0.15, 0.5, and 1.5 mg/kg/day.  These doses are up to 3 times (mice) and 2 times (rats) in terms of mg/m²/day the potential exposure at the maximum recommended human dose (MRHD), assumed to be 2.5 grams DIFFERIN Gel, 0.3%.  In the oral study, increased incidence of benign and malignant pheochromocytomas in the adrenal medullas of male rats was observed.

No photocarcinogenicity studies were conducted.  Animal studies have shown an increased risk of skin neoplasms with the use of pharmacologically similar drugs (e.g., retinoids) when exposed to UV irradiation in the laboratory or to sunlight.  Although the significance of these studies to human use is not clear, patients should be advised to avoid or minimize exposure to either sunlight or artificial UV irradiation sources.

Adapalene did not exhibit mutagenic or genotoxic effects in vitro (Ames test, Chinese hamster ovary cell assay, mouse lymphoma TK assay) and in vivo (mouse micronucleus test).

Reproductive function and fertility studies were conducted in rats administered oral doses of adapalene in amounts up to 20 mg/kg/day (up to 26 times the MRHD based on mg/m² comparisons).  No effects of adapalene were found on the reproductive performance or fertility of the F males or females.  There were also no detectable effects on the growth, development and subsequent reproductive function of the F offspring.

The safety and efficacy of once daily use of DIFFERIN Gel, 0.3% for treatment of acne vulgaris were assessed in one 12 week, multi-center, controlled, clinical study, conducted in a total of 653 patients 12 to 52 years of age with acne vulgaris of mild to moderate severity.  All female patients of child-bearing potential enrolled in the study were required to have a negative urine pregnancy test at the beginning of the study and were required to practice a highly effective method of contraception during the study.  Female patients who were pregnant, nursing or planning to become pregnant were excluded from the study.

Patients enrolled in the study were Caucasian (72%), Hispanic (12%), African-American (10%), Asian (3%), and other (2%).  An equal number of males (49.5%) and females (50.5%) enrolled.  Success was defined as "Clear" or "Almost Clear" in the Investigator’s Global Assessment (IGA).  The success rate, mean reduction, and percent reduction in acne lesion counts from Baseline after 12 weeks of treatment are presented in the following table:

Table 3: Clinical study primary efficacy results at Week 12
DIFFERIN
(adapalene)
Gel, 0.3%
Adapalene
Gel, 0.1%
Vehicle
Gel
N = 258 N = 261 N = 134
IGA Success Rate 53 (21%) 41 (16%) 12 (9%)
Inflammatory Lesions
       Mean Baseline Count
       Mean Absolute (%) Reduction

27.7
14.4 (51.6%)

28.1
13.9 (49.7%)

27.2
11.2 (40.7%)
Non-Inflammatory Lesions
       Mean Baseline Count
       Mean Absolute (%) Reduction

39.4
16.3 (39.7%)

41.0
15.2 (35.2%)

40.0
10.3 (27.2%)
Total Lesions
       Mean Baseline Count
       Mean Absolute (%) Reduction

67.1
30.6 (45.3%)

69.1
29.0 (41.8%)

67.2
21.4 (33.7%)

DIFFERIN Gel, 0.3% is supplied in the following size.

15 g tube - NDC 0299-5918-15

45 g tube – NDC 0299-5918-45

45 g pump - NDC 0299-5918-25

Storage : Store at controlled room temperature 68° to 77°F (20° to 25°C) with excursions permitted between 59° to 86°F (15° to 30°C). Protect from freezing. Keep out of reach of children.

"See FDA-approved patient labeling (Patient Information)"

Information for Patients

Patients using DIFFERIN Gel, 0.3%, should receive the following information and instructions:

Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177 USA

Manufactured by:

G Production Inc.Baie d’Urfé, QC, H9X 3S4 CanadaMade in CanadaGALDERMA is a registered trademark.

P52321-0

Or (only one manufacturer will be listed as appropriate)

Manufactured by:DPT Laboratories, Ltd.San Antonio, Texas 78215 USAGALDERMA is a registered trademark.

Patient Information DIFFERIN® [Dif-er-in] (adapalene) Gel 0.3%

Important: For use on the skin only (topical). Do not use DIFFERIN Gel, 0.3% in or on your mouth, eyes, or vagina.

Read this Patient Information that comes with DIFFERIN Gel, 0.3% before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your treatment or your medical condition. If you have any questions about DIFFERIN Gel, 0.3%, talk with your doctor or pharmacist.

What is DIFFERIN Gel, 0.3%?

DIFFERIN Gel, 0.3% is a prescription medicine for skin use only (topical) used to treat acne vulgaris in people 12 years of age and older. Acne vulgaris is a condition in which the skin has blackheads, whiteheads and pimples. It is not known if DIFFERIN Gel, 0.3% is safe and effective in children younger than 12 years of age or in people 65 years of age and older.

Who should not use DIFFERIN Gel, 0.3%?

Do not use DIFFERIN Gel, 0.3% if you:

What should I tell my doctor before using DIFFERIN Gel, 0.3%?

Before you use DIFFERIN Gel, 0.3%, tell your doctor if you:

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal supplements.

Especially tell your doctor if you use any other medicine for acne. Using DIFFERIN Gel, 0.3% with topical medicines that contain sulfur, resorcinol or salicylic acid may cause skin irritation.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

How should I use DIFFERIN Gel, 0.3%?

Applying DIFFERIN Gel, 0.3%:

- Tube: Squeeze a small amount onto your fingertips and spread a thin layer over the entire face and any other affected areas.- Pump: Depress the pump to dispense a small amount of DIFFERIN Gel, 0.3% and spread a thin layer over the entire face and any other affected area.

What should I avoid while using DIFFERIN Gel, 0.3%?

What are the possible side effects of DIFFERIN Gel, 0.3%?

DIFFERIN Gel, 0.3% may cause serious side effects including:

- Local skin reactions. Local skin reactions are most likely to happen during the first 4 weeks of treatment and usually lessen with continued use of DIFFERIN Gel, 0.3%. Signs and symptoms of local skin reaction include:

- Allergic reactions. DIFFERIN Gel, 0.3% may cause an allergic reaction that may require medical treatment. Stop using DIFFERIN Gel, 0.3% and tell your doctor right away if you have any of these symptoms of an allergic reaction:

You may use a moisturizer for relief of dry skin or irritation, however you should avoid products that contain alpha hydroxy or glycolic acid.

The most common side effects of DIFFERIN Gel, 0.3% are:

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of DIFFERIN Gel, 0.3%. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to GALDERMA LABORATORIES, L.P. at 1-866-735-4137.

How should I store DIFFERIN Gel, 0.3%?

Keep DIFFERIN Gel, 0.3% and all medicines out of the reach of children.

General information about DIFFERIN Gel, 0.3%

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information Leaflet. Do not use DIFFERIN Gel, 0.3% for a condition for which it was not prescribed. Do not give DIFFERIN Gel, 0.3% to other people, even if they have the same symptoms you have. It may harm them.

This Patient Information leaflet summarizes the most important information about DIFFERIN Gel, 0.3%. If you would like more information, talk with your doctor. You can also ask your doctor or pharmacist for information about DIFFERIN Gel, 0.3% that is written for health professionals.

What are the ingredients in DIFFERIN Gel, 0.3%?

Active ingredient: adapalene

Inactive ingredients: carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water and sodium hydroxide. May contain hydrochloric acid for pH adjustment.

This Patient Information has been approved by the U.S. Food and Drug Administration.

Marketed by:GALDERMA LABORATORIES, L.P., Fort Worth, Texas 76177 USA

Manufactured by:G Production Inc., Baie d’Urfé, QC, H9X 3S4 CanadaMade in Canada.GALDERMA is a registered trademark.P52321-0

Or (only one manufacturer will be listed as appropriate)

Manufactured by:DPT Laboratories, Ltd.San Antonio, Texas 78215 USAGalderma is a registered trademark.

Issued: 12/2013

Rx only

NDC 0299-5918-25

Differin 0.3 (adapalene) Gel, 0.3%

PUMP

FOR TOPICAL USE ONLY

NET WT. 45 g

Galderma

For topical use only. Not for ophthalmic, oral, or intravaginal use.

Usual dosage: apply a thin film once a day at nighttime to affected areas. See package insert for complete prescribing information.

Each gram contains: adapalene 0.3% (3 mg) in an aqueous gel consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide. May contain hydrochloric acid for pH adjustment.

Storage: Store at controlled room temperature 68° to 77°F (20° to 25°C) with excursions permitted between 59° to 86°F (15° to 30°C). Protect from freezing.

See carton closure for lot number and expiration date.

Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, TX 76177 USAMade in CanadaAll trademarks are the property of their respective owners. www.differin.com P51959-4

DIFFERIN (adapalene) gel, 0.3% GELFor topical use only NET WT. 45g NDC 0299-5918-45Rx only Galderma

For topical use only. Not for ophthalmic, oral, or intravaginal use.Usual dosage: Apply a thin film once a day at nighttime to affected areas. See package insert for complete prescribing information. Each gram contains: adapalene 0.3% (3 mg) in a topical aqueous gel consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide.  May also contain hydrochloric acid for pH adjustment. Storage: Store at controlled room temperature 68° to 77°F (20° to 25°C) with excursions permitted between 59° to 86°F (15° to 30°C). Protect from freezing.See carton closure for lot number and expiration date. Marketed by:GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177 USAMade in CanadaGALDERMA is a registered trademark. www.differin.comP51241-3

Manufacturer

Galderma Laboratories, L.P.

Active Ingredients

Source

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