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BPO 4% Gel and BPO'8% Gel are topical preparations containing benzoyl peroxide 4% and 8%, respectively, as the active ingredient in a gel vehicle containing purified water, aloe barbadensis leaf juice, benzyl alcohOl, cetyl alcohol, dimethyl isosorbide, simethicone, stearyl alcohol and ceteareth-20.
The exact method of action of benzoyl peroxide in acne vulgaris is not known. Benzoyd peroxide is an antibacterial agent with demonstrated activity against Propionibacterium acnes. This action, combined with the mild keratolytic effect of benzoyl peroxide is believed to be responsible for its usefulness in acne.Benzoyl peroxide is absorbed by the skin where it is metabolized to benzoic acid and excreted as benzoate in the urine.
BPO 4% Gel and BPO 8% Gel are indicated for use in the topical treatment of mild to moderate acne vulgaris. BPO 4% Gel or BPO 8% Gel may be used as an addition in acne treatment regimens including antibiotics, retinoic acid products and sulfur/salicylic acid containing preparations.
BPO 4% Gel and BPO 8% Gel should not be used in patients who have shown hypersensitivity to benzoyl peroxide or to any of the other ingredients in the product.
Contact sensitization reactions are associated with the use of topical benzoyl peroxide products and may be expected to occur in 10 to 25 of 1 000 patients. The most frequent adverse reactions associated with benzoyl peroxide use are excessive erythema and peeling which may be expected to occur in 5 of 100 patients. Excessive erythema and peeling most frequently appear during the initial phase of drug use and may normally be controlled by reducing frequency of use .
BPO 4% Gel is supplied in 42.5 g (1.5 oz) tubes NDC42192-1 05-15. BPO 8% Gel is supplied in 42.5 9 (1.5 oz) tubes NDC 421 92-106-15.Store at controlled room temperature 15°-30°C (59°·86°F).
Acella Pharmaceuticals, LLC
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