Nupro® Fluorides Acidulated Phosphate Fluoride (APF) Topical Gel | Nupro Fluorides [Dentsply LLC. Professional Division Trading as "DENTSPLY Professional"] | BioPortfolio

13:17 EST 27th January 2019 | BioPortfolio

Note: While we endeavour to keep our records up-to-date one should not rely on these details being accurate without first consulting a professional. Click here to read our full medical disclaimer.

For topical application to aid in the protection against dental caries.

1. Remove cap from bottle, remove induction seal. DO NOT USE IF SEAL IS BROKEN. 2. Replace cap and shake well. 3. Dispense a narrow ribbon of gel into applicator trays. 4. Air dry teeth thoroughly and insert trays in mouth with head tilted slightly forward. 5. Instruct patient to continue light biting action for 1 minute (or up to 4 minutes). A slight chewing motion enhances interproximal coverage. 6. Use suction throughout treatment. 7. Have patient expectorate after treatment. 8. Instruct patient not to eat, drink, or rinse for 30 minutes.

Recommended Frequency: Not to exceed four 4 treatments per year.

Hypersensitivity to fluoride.

Do not swallow. Keep out of reach of children. Safety and effectiveness below age 3 have not been established. There have been no long-term animal studies with this product to evaluate carcinogenic, mutagenic, or impairment of fertility potential. Laboratory studies have indicated that repeated use of APF may dull porcelain, composite restorations and sealants.

If treatment dose is swallowed [less than 100 mg F], administer milk, limewater, or calcium-type antacid. In case of larger doses [1 pint contains 4.5 grams F ion, which is a lethal dose], use ipecac syrup emetic and immediately seek medical help.

Developing teeth of children under age 6 may become permanently discolored if excessive amounts are repeatedly swallowed. The following adverse reactions are possible in individuals hypersensitive to fluoride: eczema, atopic dermatitis, urticaria, gastric distress, headache, and weakness.

2.59% sodium fluoride (1.23% fluoride ion) gel supplied in 12 fl. oz. bottles.

Store at room temperature. Protect from freezing.

SAFETY DATA SHEET is available on our website,, or by contacting Customer Service at 1-800-989-8826.

Manufactured For: DENTSPLY Professional 1301 Smile Way York, PA 17404 USA 1-800-989-8826

Made in the U.S.A


Dentsply LLC. Professional Division Trading as "DENTSPLY Professional"

Active Ingredients


Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

Evaluation of a Low-fluoride Anticaries Toothpaste

The purpose of this trial is to evaluate the anticaries remineralizing potential of a toothpaste containing 500 ppm fluoride plus fTCP technology relative to a commercially available tooth...

Preventive Effect of Salt Fluoridation

This was a block-randomized, controlled, open-label trial and was executed in two preschools in The Gambia. Fluoridated table salt (250 mg F/kg salt) was administered in daily communal pre...

PubMed Articles [21 Associated PubMed Articles listed on BioPortfolio]

Hydroximoyl fluorides as the precursors of nitrile oxides: synthesis, stability and 3 + 2-cycloaddition with alkynes.

The transformation of hydroximoyl fluorides to nitrile oxides for [3 + 2]-cycloaddition with alkynes has been achieved for the first time. The hydroximoyl fluorides used in this work appeared to be no...

Effectiveness of Professional Fluorides against Enamel White Spot Lesions during Fixed Orthodontic treatment: A Systematic Review and meta-analysis.

To systematically review the effectiveness of professionally applied topical fluorides in the prevention and reversal of Enamel White Spot Lesions (EWSLs) occurring during multi-bracketed fixed orthod...

LiHMDS-Promoted Palladium or Iron-Catalyzed ipso-Defluoroborylation of Aryl Fluorides.

A novel and efficient method for the synthesis of arylboronic acid pinacol esters via a palladium- or iron-catalyzed cross-coupling reaction of aryl fluorides with bis(pinacolato)diboron (Bpin) in the...

Interactions of C-F bonds with hydridoboranes: Reduction, Borylation and Friedel-Crafts Alkylation.

The stoichiometric reactions of the alkylfluorides 1-fluoroadamantane (Ad-F), fluorocyclohexane (Cy-F), 1-fluoropentane (Pent-F) and benzyl fluorides with secondary boranes pinacolborane (HBpin), cate...

A new reductive dl-mandelic acid loading approach for moisture-stable Mn doped fluorides.

In this communication, a novel reductive dl-mandelic acid loading approach for moisture-stable Mn4+ doped fluorides is reported. After loading dl-mandelic acid, the characteristic luminescence propert...

Quick Search


Relevant Topics

Dentistry is the study, management and treatment of diseases and conditions affecting the mouth, jaw, teeth and their supporting tissues (Oxford Medical Dictionary) The work of a dentist ranges from regular patient check-up to orthodontics and surgery....

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Drugs and Medication Quicklinks

Searches Linking to this Drug Record