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ESTRADIOL | ESTRADIOL [DirectRX] | BioPortfolio

13:19 EST 27th January 2019 | BioPortfolio

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Estradiol Tablets USP for oral administration contains 0.5, 1 or 2 mg of micronized estradiol per tablet. Estradiol (17β-estradiol) is a white, crystalline solid, chemically described as estra-1,3,5,(10)-triene-3, 17β-diol. The structural formula is:

Estradiol Structural Formula

Inactive Ingredients: Colloidal silicon dioxide, corn starch, dibasic calcium phosphate, lactose monohydrate, magnesium stearate, and sodium starch glycolate. In addition, the 1 mg also contains FD&C blue no. 1 aluminum lake and D&C red no. 27 aluminum lake. The 2 mg also contains FD&C blue no. 1 aluminum lake and FD&C yellow no. 5 (tartrazine) aluminum lake.

Manufacturer

DirectRX

Active Ingredients

Source

Drugs and Medications [97 Associated Drugs and Medications listed on BioPortfolio]

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ELESTRIN (estradiol gel)

Estradiol / norethindrone acetate [physicians total care, inc.]

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Clinical Trials [359 Associated Clinical Trials listed on BioPortfolio]

Multi-Center Study to Evaluate Estradiol Transdermal Spray in the Treatment of Symptomatic Postmenopausal Women

Estradiol treatment is effective at reducing vasomotor symptoms (eg, hot flushes) in postmenopausal women. Vivus has a proprietary spray delivery system (Evamist) for estradiol. This stu...

Prevention of Obesity in Women Via Estradiol Regulation

The purpose of this study is to evaluate potential mechanisms by which estradiol deficiency accelerates fat gain and abdominal fat accumulation in women.

Drug Utilization Study on the Prescribing Indications for Cyproterone Acetate and Ethinyl Estradiol in 5 European Countries

This study is designed to compile the reasons and specific indications for the prescription of Cyproterone Acetate combined with Ethinyl Estradiol by Health Care Providers. The primary obj...

Dose Finding Study of Contraceptive Vaginal Ring With Different Estradiol Levels in Combination With Nestorone

This clinical trial investigates a new vaginal delivery system made of silicone rubber, containing Nestorone®, a 19—nor progesterone derivative and a low dose of serum estradiol (E2). T...

Comparison of Efficacy and Safety of Norgestimate-ethinyl Estradiol and Cyproterone Acetate-ethinyl Estradiol in the Treatment of Acne Vulgaris

The purpose of this study was to evaluate the effectiveness and safety of norgestimate-ethinyl estradiol as comparted with cyproterone acetate-ethinyl estradiol among female patients with ...

PubMed Articles [375 Associated PubMed Articles listed on BioPortfolio]

Estradiol matrix patches for pubertal induction: stability of cut pieces at different temperatures.

Transdermal estradiol patches are primarily designed for adult women. No low-dose patches are licensed for pubertal induction in hypogonadal girls. Low doses can be achieved by cutting a matrix patch ...

Synthesis of Benzoylbenzamide Derivatives of 17α-E-Vinyl Estradiol and Evaluation as Ligands for the Estrogen Receptor-α Ligand Binding Domain.

A series consisting of substituted benzoylbenzamide derivatives of 17α-E-vinyl estradiol 6a-i and 7a-d was prepared in good overall yields from the corresponding novel iodinated benzoylbenzamide prec...

Estradiol and progesterone bioavailability for moderate to severe vasomotor symptom treatment and endometrial protection with the continuous-combined regimen of TX-001HR (oral estradiol and progesterone capsules).

In the REPLENISH trial, women receiving TX-001HR-an oral, softgel capsule, combining 17β-estradiol (E2) and progesterone (E2 mg/P4 mg 1/100, 0.5/100), had significantly improved vasomotor symptoms, w...

Development and validation of a LC-MS/MS assay for quantification of serum estradiol using calibrators with values assigned by the CDC reference measurement procedure.

Estradiol was historically measured by gas chromatography-mass spectrometry before development of immunoassays. Although immunoassays were fast requiring low sample volume, they had specificity issues...

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis.

This study aimed to investigate the action mechanism of β-estradiol in MCF-7 breast cancer (BC) cells.

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