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CEPHALEXIN | CEPHALEXIN [DirectRX] | BioPortfolio

13:25 EST 27th January 2019 | BioPortfolio

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To reduce the development of drug-resistant bacteria and maintain the effectiveness of cephalexin and other antibacterial drugs, cephalexin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Cephalexin capsules, USP is a semisynthetic cephalosporin antibiotic intended for oral administration. It is 7-(D-α-Amino-α-phenylacetamido)-3-methyl-3-cephem-4- carboxylic acid monohydrate. Cephalexin has the molecular formula C16H17N3O4S∙H2O and the molecular weight is 365.41.

Cephalexin has the following structural formula:

Chemical Structure

The nucleus of cephalexin is related to that of other cephalosporin antibiotics. The compound is a zwitterion; i.e., the molecule contains both a basic and an acidic group. The isoelectric point of cephalexin in water is approximately 4.5 to 5. The crystalline form of cephalexin which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty.

The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Cephalexin has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3-position.

Each capsule contains cephalexin monohydrate equivalent to 250 mg or 500 mg of cephalexin. The capsules also contain anhydrous lactose, gelatin, magnesium stearate, talc and titanium dioxide. The capsules are imprinted with edible ink containing black iron oxide.

Cephalexin capsules are contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Manufacturer

DirectRX

Active Ingredients

Source

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Clinical Trials [21 Associated Clinical Trials listed on BioPortfolio]

A Study of Cephalexin Liquid in Healthy Participants

The purpose of this study is to compare two different preparations of an antibiotic called cephalexin to determine if they are essentially the same. The study has two periods. Participants...

Antibiotics for Prevention of SSI in Obese Women Undergoing CS

Effect of cephalexin plus metronidazole on SSI better than cephalexin alone in obese women undergoing CS

Ciprofloxacin Compared With Cephalexin in Treating Patients With Bladder Cancer

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. It is not yet known whether ciprofloxacin is more effective than c...

Cross Over Study to Prove Bioequivalence Between Two Brands of Cefalexin Suspension

A single dose, two treatments (two cephalexin suspension brands), two sequences, cross-over design was used with a washout of 7 days between the two study periods. Treatment groups balance...

Cross-over Study to Prove Bioequivalence Between Two Brands of Cefalexin Capsules

A single dose, two treatments (two cephalexin capsules brands), two sequences, cross-over design was used with a washout of 7 days between the two study periods. Treatment groups balanced...

PubMed Articles [14 Associated PubMed Articles listed on BioPortfolio]

Draft genome sequence of Xenophilus sp.E41 isolated from activated sludge reactors treating wastewater with high cephalexin concentration.

The draft genome sequence of Xenophilus sp. E41, a multiple antibiotics resistant strain isolated from activated sludge reactors treating wastewater with high cephalexin concentration, was reported in...

Sniffing out resistance - Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.

Antibiotic resistance is set to be an unprecedented threat to modern medicine. 'Sniffing' bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is ...

Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties.

3D porous scaffolds based on agarose and nanocrystalline apatite, two structural components that act as a temporary mineralized extracellular matrix, were prepared by the GELPOR3D method. This shaping...

Single-step pyrolysis of phosphoric acid-activated chitin for efficient adsorption of cephalexin antibiotic.

Cephalexin (CFX) antibiotic, a potent pharmaceutical water pollutant, was efficiently removed by activated carbon (AC) derived from a single-step pyrolysis of phosphoric acid-activated chitin. Experim...

N, Ag co-doped TiO mediated modified in-situ dual process (modified photocatalysis and photo-Fenton) in fixed-mode for the degradation of Cephalexin under solar irradiations.

Novel FeNAgTiO composite beads possessing unusual characteristics of modified in-situ dual process (modified photocatalysis and photo-Fenton) resulted in reduction in treatment time of Cephalexin (CEX...

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