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DIVALPROEX SODIUM | DIVALPROEX SODIUM [DirectRX] | BioPortfolio

13:40 EST 27th January 2019 | BioPortfolio

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Divalproex sodium delayed-release tablets are supplied as:

125 mg Orange colored tablets

250 mg Pink colored tablets

500 mg Reddish pink colored tablets

Overdosage with valproate may result in somnolence, heart block, deep coma and hypernatremia. Fatalities have been reported; however patients have recovered from valproate levels as high as 2,120 mcg/mL.

In overdose situations, the fraction of drug not bound to protein is high and hemodialysis or tandem hemodialysis plus hemoperfusion may result in significant removal of drug. The benefit of gastric lavage or emesis will vary with the time since ingestion. General supportive measures should be applied with particular attention to the maintenance of adequate urinary output.

Naloxone has been reported to reverse the CNS depressant effects of valproate overdosage. Because naloxone could theoretically also reverse the antiepileptic effects of valproate, it should be used with caution in patients with epilepsy.

Manufacturer

DirectRX

Active Ingredients

Source

Drugs and Medications [55 Associated Drugs and Medications listed on BioPortfolio]

Divalproex sodium [wockhardt limited]

These highlights do not include all the information needed to use Divalproex sodium extended release tablets safely and effectively.See full prescribing information for divalproex sodium extended rele...

Divalproex sodium [dr. reddy's laboratories ltd]

NA

Divalproex sodium [wockhardt limited]

Divalproex Sodium Delayed-Release Tablets, USP Rx only

Valproic acid [ncs healthcare of ky, inc dba vangard labs]

Valproic Acid Capsules

Divalproex sodium [impax generics]

These highlights do not include all the information needed to use DIVALPROEX SODIUM EXTENDED-RELEASE TABLETS safely and effectively. See full prescribing information for DIVALPROEX SODIUM EXTENDED-...

Clinical Trials [1751 Associated Clinical Trials listed on BioPortfolio]

Divalproex Sodium vs. Placebo in Childhood/Adolescent Autism

The study is designed to assess the efficacy of treatment with divalproex sodium (DS) vs. placebo in childhood/adolescent autism fulfilling DSM-IV and Autism Diagnostic Interview (ADI) cri...

Bioequivalence Study of Dr. Reddy's Divalproex Sodium Coated Particles in Capsules, 125 mg, Under Fed Condition

An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose, crossover, bioequivalence study of Divalproex Sodium coated particles in capsules 125 mg with Dep...

Risperidone and Divalproex Sodium With MRI Assessment in Pediatric Bipolar

There are two purposes for this project. Study 1 is to determine whether risperidone is better than divalproex sodium in treating/stabilizing pediatric bipolar disorder. Study 2 is to loo...

Bioequivalence Study of Dr. Reddy's Divalproex Sodium Capsules (Sprinkle), 125 mg Under Fasting Conditions

An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose, crossover, bioequivalence study of Divalproex Sodium coated particles in capsules 125 mg with Dep...

Bioequivalence Study of Divalproex Sodium 125 MG Delayed Release Tablets Under Fasting Conditions

The purpose of this study is to demonstrate the bioequivalence of divalproex sodium 125 MG delayed release tablets.

PubMed Articles [1714 Associated PubMed Articles listed on BioPortfolio]

The subfornical organ in sodium appetite: recent insights.

To maintain sodium homeostasis, animals will readily seek and ingest salt when salt-depleted, even at concentrations that they typically find aversive when sodium replete. This innate behaviour is kno...

Association of usual 24-h sodium excretion with measures of adiposity among adults in the United States: NHANES, 2014.

Both excessive sodium intake and obesity are risk factors for hypertension and cardiovascular disease. The association between sodium intake and obesity is unclear, with few studies assessing sodium i...

Dialysate sodium concentration: The forgotten salt shaker.

The concentration of sodium in dialysis fluid, a major determinant of extracellular fluid volume and blood pressure, plays a major role in the sodium balance in end-stage renal disease patients. A low...

Effects of the Inhibition of Late Sodium Current by GS967 on Stretch-Induced Changes in Cardiac Electrophysiology.

Mechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a triazolopyridine derivative, is a sodium channel blocker with preferential effects o...

Sodium Houttuyfonate Inhibits Voltage-Gated Peak Sodium Current and Anemonia Sulcata Toxin II-Increased Late Sodium Current in Rabbit Ventricular Myocytes.

Sodium houttuyfonate (SH), a chemical compound originating from Houttuynia cordata, has been reported to have anti-inflammatory, antibacterial, and antifungal effects, as well as cardioprotective effe...

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