APAP 500 | APAP 500

01:06 EDT 5th May 2013 | BioPortfolio

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Cypress Pharmaceutical, Inc.

Active Ingredients


Clinical Trials [36 Associated Clinical Trials listed on BioPortfolio]

Evaluation of APAP With SensAwake in OSA and Insomnia Patients

The hypothesis is that APAP with SensAwake improves wake-after sleep onset compared to APAP without SensAwake in a patient population with Obstructive Sleep Apnea Syndrome (OSAS) and Insom...

Evaluation of the Interaction Between Acetaminophen and Zidovudine

To determine if zidovudine (AZT) and acetaminophen (APAP) interact when given to the same patient, and if so, the manner of interaction. Patients with AIDS often require therapy with paink...

Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm

The objective of this study is to determine whether acetaminophen (APAP), N-acetylcysteine (NAC), and APAP in combination with NAC will inhibit lipid peroxidation in aneurysmal subarachnoi...

Comparing Five Oral Analgesics for Treatment of Acute Pain in the ED

This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibupr...

Stroke and CPAP Outcome Study 2

Obstructive sleep apnea (OSA) is associated with impaired stroke recovery. Treatment with continuous positive airway pressure (CPAP) may prevent this but is limited by poor adherence. In t...

PubMed Articles [35 Associated PubMed Articles listed on BioPortfolio]

Multiple Admissions for Acetaminophen (APAP) Overdose: APAP Frequent Fliers, a New Entity?

Augmenter of Liver Regeneration Protects Against Acetaminophen-Induced Acute Liver Injury in Mice by Promoting Autophagy.

Most cases of acute liver failure are caused by acetaminophen (APAP) overdose. Oxidative stress is a key factor in APAP toxicity. While augmenter of liver regeneration (ALR) has both anti-oxidative an...

Acetaminophen-induced Liver Injury is Attenuated in Transgenic fat-1 Mice Endogenously Synthesizing Long-chain n-3 Fatty Acids.

Acetaminophen (APAP) overdose-caused hepatotoxicity is the most commonly cause of drugs-induced liver failurecharacterized by oxidative stress, mitochondrial dysfunction, and cell damage. Therapeutic ...

Transformation of acetaminophen in natural surface water and the change of aquatic microbes.

The kinetics and transformation pathway of acetaminophen (APAP) in natural surface water (one sample from the Yangtze River and three others from different lakes), and the changes of aquatic microbes ...

Reactive Metabolite-induced Protein Glutathionylation: a Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity.

Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induc...

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