Diphenhydramine | Diphenhydramine HCl

04:31 EDT 27th August 2014 | BioPortfolio

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*Compare to Benadryl®

Diphenhydramine 25mg and 50mg


Relieves sneezing, runny nose, itchy, watery eyes & itchy throat

1000 Tablets


Drug Facts

(in each tablet)

Diphenhydramine HCl 25 mgDiphenhydramine HCl 50 mg


temporarily relieves these symptoms due to hay fever or other upper respiratory allergies and common cold

Do not use

before use if you are taking sedatives or tranquilizers.

ask a health care professional before use.

In case of overdose, get medical help or contact a Poison Control Center right away.

25 mg Directions

50 mg Directions

*Do not attempt to break capsule. The proper dosage strength and dosing information for children under 12 years of age is available in the 25 mg package.

adults and children 12 years of age and over take 25 mg to 50 mg (1 to 2 capsules) every 4 to 6 hours, not to exceed 12 capsules in 24 hours
children 6 to under 12 years of age take 25 mg (1 capsule) every 4 to 6 hours, not to exceed 6 capsules in 24 hours
children under 6 years of age consult a physician
adults and children 12 years of age and over take 50 mg (1 capsule) every 4 to 6 hours, not to exceed 6 capsules in 24 hours
children under 12 years of age consult a physician, the proper dosage strength is not available in this package*

Other information

D&C Red #28, FD&C Blue #1, FD&C Red #40, Gelatin, Lactose and  Starch.

Manufactured by: CONTRACT PHARMACAL CORP135 Adams Ave., Hauppauge, NY 11788 USA

R 02/11

IMAGE 5fa1d326-figure-01.jpgIMAGE 5fa1d326-figure-02.jpg


Contract Pharmacal Corp

Active Ingredients


Clinical Trials [49 Associated Clinical Trials listed on BioPortfolio]

A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects

To evaluate the relative bioavailability of Naproxen Sodium 220 mg and diphenhydramine hydrochloride (DPH HCL) 25 mg soft capsules (Test) versus Naproxen Sodium 220 mg and diphenhydramine ...

Bioequivalence Between Two Oral Formulations of Diphenhydramine Hydrochloride

The purpose of this study is to determine if two formulations of diphenhydramine hydrochloride are bioequivalent.

Study to Evaluate Diphenhydramine in Children and Adolescents

To characterize the pharmacokinetics of diphenhydramine in two pediatric populations: children, ages 2 to < 12 years, and adolescents, ages 12 to < 18 years.

Evaluation of Diphenhydramine Hydrochloride Effects in Subjects With Occasional Sleeplessness

The present study was conducted to investigate the impact of diphenhydramine hydrochloride on the ability to initiate sleep.

Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition

To determine the single-dose oral bioequivalence study of Ibuprofen and Diphenhydramine citrate 200 mg/38 mg caplets of Dr. Reddy's Laboratories Limited, India and Advil®PM, of Wyeth cons...

PubMed Articles [14 Associated PubMed Articles listed on BioPortfolio]

Extrapyramidal signs occurring after sympathetic block for complex regional pain syndrome responding to diphenhydramine: Two case reports.

To present an unusual extrapyramidal motor response occurring after a sympathetic block in CRPS and its successful treatment with diphenhydramine.

Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study).

 We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison.

Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine.

The Research to Practice Column is designed to improve translational research critique skills of nurse practitioners (NPs). In this issue, the article "Randomized study of IV prochlorperazine plus dip...

Preparation, characterization, and formulation development of drug-drug protic ionic liquids of diphenhydramine with ibuprofen and naproxen.

Diphenhydramine (DPH) has been used with ibuprofen (IBU) or naproxen (NAP) in combined therapies to provide better clinical efficacy as an analgesic and sleep aid. We discovered that DPH can form prot...

Fundamental study of the ultrasonic induced degradation of the popular antihistamine, diphenhydramine (DPH).

Diphenhydramine (DPH) the active ingredient in Benadryl, has been detected in streams, rivers and other surface water sources. As a bioactive compound, DPH impacts human health even at low concentrati...

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