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Latest Biotechnology, Pharmaceutical and Healthcare PubMed Articles

07:35 EST 23rd February 2019 | BioPortfolio

Genome rearrangements are global mutations that change large stretches of DNA sequence throughout genomes. They are rare but accumulate during the evolutionary process leading to organisms with similar genetic material in different places and orientations within the genome. Sorting by Genome Rearrangements problems seek for minimum-length sequences of rearrangements that transform one genome into ...

We aimed to explore the roles of circular RNAs (circRNAs) in breast cancer (BCa).

Patients undergoing open-heart surgery may suffer from postoperative complications, including severe infections. Antimicrobials to treat infectious complications in this population should be selected thoughtfully, taking into account three different and fundamental issues: (i) the site of infection; (ii) the suspected or proven causative agent and its susceptibility pattern; and (iii) the risk of ...

A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region.

High-resolution computed tomography (HRCT) imaging has an increasingly important role in clinical decision-making in patients with interstitial lung diseases. The recent Fleischner Society white paper on the diagnostic criteria for idiopathic pulmonary fibrosis highlights the advances in our understanding of HRCT imaging in interstitial lung diseases.

Cervical adenocarcinomas are a heterogeneous group of tumors with varying morphologies, etiologies, molecular drivers, and prognoses, comprising approximately 25% of all cervical cancers. Unlike cervical squamous cell carcinoma, adenocarcinomas are not uniformly caused by high-risk human papillomavirus (HPV) infection and, therefore, would not necessarily be prevented by the HPV vaccine.

Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Therefore, intraoperative frozen section evaluation is crucial for determining the required extent...

We aimed to explore potential regulators of coding and noncoding RNAs (ncRNAs) in Co(II) ion-induced myo cytotoxicity.

Insights in RNA biology have opened up a plethora of opportunities to explore the small regulatory RNAs from various natural and artificial sources. These small RNAs have been suggested to play a role too in tumor progression by either as oncogenic or tumor suppressor small RNAs. In this study, authors have attempted to evaluate the therapeutic potential of small RNAs fractionated from corn (Zea m...

Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine. Pregnant women with evidence of SPS during the first trimester have an increased risk of developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized mar...

MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit sKlotho. This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho.

Predicting the location of the translation initiation sites (TIS) is an important problem of molecular biology. In this field, the computational cost for balancing non-TIS sequences is substantial and demands high-performance computing. In this article, we present an optimized version of the K-modes algorithm to cluster TIS sequences and a comparison with the standard K-means clustering. The adapt...

MMP13 deficiency in pulmonary fibrosis have described contradictory phenotypes on inflammatory and fibrotic responses after lung injury and its role during lung fibrosis resolution is still undefined. MMP13 has been considered the main collagenase in rodents, and the remodeling of fibrillar collagen is widely attributed to the action of this enzyme. In this study we aimed to explore the role of MM...

Monocrotaline has been widely used to establish an animal model of pulmonary hypertension, most frequently in rats. An important feature of this model resides in the selectivity of monocrotaline injury towards the pulmonary vascular endothelium versus the systemic vasculature when administrated at standard dosage. The toxic metabolite of monocrotaline, monocrotaline pyrrole, is transported by eryt...

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors and remodeling proteins (senescence associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis and proliferation, while hindering tissue repair and regeneratio...

Paracrine erythropoietin (EPO) signaling in the lung recruits endothelial progenitor cells, promotes cell maturation and angiogenesis , and is upregulated during canine post-pneumonectomy (PNX) compensatory lung growth. To determine whether inhalational delivery of exogenous EPO augments endogenous post-PNX lung growth, adult canines underwent right PNX and received, via a permanent tracheal stoma...

We propose a new model for fast classification of DNA sequences output by next-generation sequencing machines. The model, which we call fastDNA, embeds DNA sequences in a vector space by learning continuous low-dimensional representations of the k-mers it contains. We show on metagenomics benchmarks that it outperforms the state-of-the-art methods in terms of accuracy and scalability.

Vascular access is the lifeline for hemodialysis patients. Arteriovenous fistulas (AVFs) are the preferred vascular access but AVF maturation failure remains a significant clinical problem. Currently there are not any effective therapies available to prevent or treat AVF maturation failure. AVF maturation failure frequently results from venous stenosis at the AVF anastomosis, which is secondary to...

The objective of this study was to investigate theoretically the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors including Na, parathyroid hormone (PTH), Angiotensin II, and SGLT2 inhibitors. To that end, we incorporated the transport of uric acid and its conjugate anion urate in our mathematical model of water and solute transp...

Balb/CJ mice are more sensitive to treatment with Angiotensin II (AngII) and high salt (Salt) diet compared to C57BL/6J. Together with higher mortality, they develop edema, signs of heart failure and acute kidney injury. The aim of the present study was to identify differences in renal gene regulation that may affect kidney function and fluid balance, which could contribute to decompensation in Ba...

Kidney normothermic machine perfusion (NMP) has historically employed a 95% O/5% CO gas mixture. Using a porcine model of organ retrieval, NMP and reperfusion, we tested the hypothesis that reducing perfusate oxygenation (PO) would be detrimental to renal function and cause injury. In a minimal-ischemic-injury (MI) experiment, kidneys sustained 10min of warm ischemia (WI) and 2hr of static cold st...

Inhibition of p53 has been shown to be an efficient strategy for ameliorating kidney ischemia/reperfusion (I/R) injury in experimental models. The therapeutic value of p53 siRNA based inhibition for I/R in renal transplantation is currently evaluated in clinical studies. While the major rationale for these studies is the suppression of pro-apoptotic properties, there are more, equally important in...

Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic administration of the Schistosomiasis haematobium-derived protein H-IPSE (IL-4-inducing principle from Schistosoma mansoni eggs), is superior to 3 doses of M...

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