Genetic screen reveals link between maternal-effect sterile gene mes-1 and P. aeruginosa-Induced neurodegeneration in C. elegans.

08:00 EDT 16th October 2015 | BioPortfolio

Summary of "Genetic screen reveals link between maternal-effect sterile gene mes-1 and P. aeruginosa-Induced neurodegeneration in C. elegans."

Increasing evidence indicates that immune responses to microbial infections may contribute to neurodegenerative diseases. Here, we show that Pseudomonas aeruginosa infection of Caenorhabditis elegans causes a number of neural changes that are hallmarks of neurodegeneration. Using an unbiased genetic screen to identify genes involved in the control of P. aeruginosa-induced neurodegeneration, we identified mes-1, which encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline. We showed that sterile but not fertile mes-1 animals were resistant to neurodegeneration induced by P. aeruginosa infection. Similar results were observed using animals carrying a mutation in the maternal-effect gene pgl-1, which is required for postembryonic germline development, and the germline-deficient strains glp-1 and glp-4. Additional studies indicated that the FOXO transcription factor DAF-16 is required for resistance to P. aeruginosa-induced neurodegeneration in germline-deficient strains. Thus, our results demonstrate that P. aeruginosa infection results in neurodegeneration phenotypes in C. elegans that are controlled by the germline in a cell-nonautonomous manner.


Journal Details

This article was published in the following journal.

Name: The Journal of biological chemistry
ISSN: 1083-351X


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Medical and Biotech [MESH] Definitions

Transmission of genetic characters, qualities, and traits, solely from maternal extra-nuclear elements such as MITOCHONDRIAL DNA or MATERNAL MESSENGER RNA.

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