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FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK.

07:00 EST 1st January 2000 | BioPortfolio

Summary of "FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK."

The inhibitory Fc receptor, FcγRIIB, has emerged as a key negative regulator of B cell activation and as such is predicted to play an essential role in controlling antibody-mediated autoimmune diseases in humans. Recent studies have shown that crosslinking the FcγRIIB independently of the B-cell receptor (BCR) results in apoptosis in both mouse and chicken B cells. However, the human B cell subpopulations that are susceptible to BCR-independent, FcγRIIB-mediated regulation are not known. How FcγRIIB mediates this inhibition to affect B cell homeostasis is also not determined.

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This article was published in the following journal.

Name: Journal of biomedical science
ISSN: 1423-0127
Pages: 87

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