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High Expression of Cathepsin E is Associated with the Severity 
of Airflow Limitation in Patients with COPD.

08:00 EDT 21st October 2015 | BioPortfolio

Summary of "High Expression of Cathepsin E is Associated with the Severity 
of Airflow Limitation in Patients with COPD."

It was reported that Cathepsin E (Cat E) plays a critical role in antigen processing and in the development of pulmonary emphysema. The aim of this study was to investigate the role of Cat E and airflow limitation in the pathogenesis of COPD.

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Journal Details

This article was published in the following journal.

Name: COPD
ISSN: 1541-2563
Pages: 1-7

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Medical and Biotech [MESH] Definitions

An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the cells of the immune system where it may play a role in processing of CELL SURFACE ANTIGENS.

A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.

A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.

Levels of severity of illness within a diagnostic group which are established by various measurement criteria.

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