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Pulmonary but not subcutaneous vaccination confers protection to TB susceptible mice by an IL17-dependent mechanism.

08:00 EDT 22nd October 2015 | BioPortfolio

Summary of "Pulmonary but not subcutaneous vaccination confers protection to TB susceptible mice by an IL17-dependent mechanism."

Some of the most promising novel tuberculosis (TB) vaccine strategies currently under development are based on respiratory vaccination, mimicking the natural route of infection. In this work, we have compared pulmonary and subcutaneous BCG immunization in the TB susceptible DBA/2 mouse strain, a model in which parenteral BCG does not protect. Our data show that intranasal but not subcutaneous BCG confers robust protection against pulmonary TB challenge. In addition, our results indicate that pulmonary vaccination triggers a TB-specific mucosal immune response orchestrated by IL17A. Thus, IL17A neutralization in vivo reduces protection, as well as it abrogates TB-specific IgA secretion to respiratory airways and lung expression of pIgR induced following intranasal vaccination. Altogether, our results demonstrate that pulmonary BCG vaccination can overcome lack of protection observed when BCG is given by parenteral route, suggesting that respiratory TB vaccines could have an advantage in TB endemic countries, where intradermal BCG results inefficient against pulmonary TB.

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This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613
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Medical and Biotech [MESH] Definitions

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

The type species of BETARETROVIRUS commonly latent in mice. It causes mammary adenocarcinoma in a genetically susceptible strain of mice when the appropriate hormonal influences operate.

A species of HANTAVIRUS which emerged in the Four Corners area of the United States in 1993. It causes a serious, often fatal pulmonary illness (HANTAVIRUS PULMONARY SYNDROME) in humans. Transmission is by inhaling aerosolized rodent secretions that contain virus particles, carried especially by deer mice (PEROMYSCUS maniculatus) and pinyon mice (P. truei).

Group activities directed against VACCINATION.

Rate of VACCINATION as defined by GEOGRAPHY and or DEMOGRAPHY.

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