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The electron transfer (ET) properties of two types of high-valent hemes were studied within the same protein matrix; the bis -Fe(IV) state of MauG and the Compound I state of Y294H MauG. The latter is formed as a consequence of mutation of the Tyr which forms the distal axial ligand of the six-coordinate heme that allows it to stabilize FeIV in the absence of an external ligand. The rates of the ET reaction of each high-valent species with the type I copper protein, amicyanin, were determined at different temperatures and analyzed by ET theory. The reaction with bis -Fe(IV) WT MauG exhibited a reorganization energy (λ) that was 0.39 eV greater than that for the reaction of Compound I Y295H MauG. It is concluded that the delocalization of charge over the two hemes in the bis -Fe(IV) state is responsible for the larger λ, relative to the Compound I state in which the Fe(V) equivalent is isolated on one heme. While the increase in λdecreases the rate of ET, the delocalization of charge decreases the ET distance in its natural substrate protein, thus increasing the ET rate. This describes how proteins can balance different ET properties of complex redox cofactors to optimize each system for its particular ET or catalytic reaction.
This article was published in the following journal.
Name: The Biochemical journal
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