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Understanding Aspects of aluminum exposure in Alzheimer's disease development.

08:00 EDT 23rd October 2015 | BioPortfolio

Summary of "Understanding Aspects of aluminum exposure in Alzheimer's disease development."

Aluminum is a ubiquitously abundant non-essential element. Aluminum has been associated with neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and dialysis encephalopathy. Many continue to regard aluminum as controversial although increasing evidence supports the implications of aluminum in the pathogenesis of Alzheimer's disease. Aluminum causes the accumulation of tau protein and Aβ protein in the brain of experimental animals. Aluminum induces neuronal apoptosis in vivo and in vitro, either by endoplasmic stress from the unfolded protein response, by mitochondrial dysfunction, or a combination of them. Some, people who are exposed chronically to aluminum, either from through water and/or food, have not shown any Alzheimer's disease pathology, apparently because their gastrointestinal barrier is more effective. This article is written keeping in mind mechanisms of action of aluminum neurotoxicity with respect to Alzheimer's disease. This article is protected by copyright. All rights reserved.

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Name: Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
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