Impact of Tobacco Smoke and Nicotine Exposure on Lung Development.

08:00 EDT 22nd October 2015 | BioPortfolio

Summary of "Impact of Tobacco Smoke and Nicotine Exposure on Lung Development."

Tobacco smoke and nicotine exposure during prenatal and postnatal life can impair lung development, alter the immune response to viral infections and increase the prevalence of wheezing during childhood. The following review examines recent discoveries in the fields of lung development and tobacco/nicotine exposure, emphasizing studies published within the last five years. In utero tobacco/nicotine exposure remains common, occurring in approximately 10% of pregnancies within the United States. Exposed neonates are at increased risk for diminished lung function, altered central and peripheral respiratory chemoreception and increased asthma symptoms throughout childhood. Recently, genomic and epigenetic risk factors, such as alterations in DNA methylation, have been identified that may influence the risk for long-term disease. This review examines the impact of prenatal tobacco/ nicotine exposure on lung development with a particular focus on nicotinic acetylcholine receptors. In addition this review examines the role of prenatal and postnatal tobacco smoke/nicotine exposure and its association with augmenting infection risk, skewing the immune response towards a Th2 bias and increasing risk for developing an allergic phenotype and asthma-like symptoms during childhood. Finally this review outlines the respiratory morbidities associated with childhood secondhand smoke/nicotine exposure and examines genetic and epigenetic modifiers that may influence respiratory health in infants and children exposed to in utero or postnatal tobacco smoke.


Journal Details

This article was published in the following journal.

Name: Chest
ISSN: 1931-3543


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Medical and Biotech [MESH] Definitions

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Prohibition against tobacco smoking in specific areas to control TOBACCO SMOKE POLLUTION.

Contamination of the air by tobacco smoke.

The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.

Inhaling and exhaling the smoke of tobacco or something similar to tobacco.

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