A Unified Approach to the Isomeric α-,β-,γ- and δ-Carbolines via their 6,7,8,9-Tetrahydro-counterparts.

08:00 EDT 17th March 2017 | BioPortfolio

Summary of "A Unified Approach to the Isomeric α-,β-,γ- and δ-Carbolines via their 6,7,8,9-Tetrahydro-counterparts."

A cross-coupling/reductive cyclisation protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which is readily prepared through an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6.7,8,9-tetrahydro-α-carboline (9) that is itself readily aromatized to give α-carboline (1).


Journal Details

This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904


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