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Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.

08:00 EDT 17th April 2017 | BioPortfolio

Summary of "Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease."

The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a risk factor for coronary artery disease; however, this possibility has never been tested.

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This article was published in the following journal.

Name: PloS one
ISSN: 1932-6203
Pages: e0175649

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Medical and Biotech [MESH] Definitions

A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.

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