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The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion injury in rats. Forty female Wistar albino rats were randomly divided into five groups: Group
ischemia (I), Group
ischemia-reperfusion (I/R), Group
ischemia-reperfusion (I/R) + Tempol 30 mg/kg i.p, Group
ischemia-reperfusion + Tempol 50 mg/kg i.p. Oxidative Stress Index (OSI) was significantly higher in the ischemia group and the I/R group compared with the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + Tempol 30 mg/kg i.p. and the I/R + Tempol 50 mg/kg i.p. group. Glutathione peroxidase levels were lower in the I/R group than in the I/R + Tempol 30 mg/kg i.p. and the I/R + Tempol 50 mg/kg i.p. group. MDA levels were significantly lower in the I/R + Tempol 30 mg/kg i.p. group and the I/R + Tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + Tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian ischemia reperfusion injury.
This article was published in the following journal.
Name: Canadian journal of physiology and pharmacology
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Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
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