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The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion injury in rats. Forty female Wistar albino rats were randomly divided into five groups: Group
ischemia (I), Group
ischemia-reperfusion (I/R), Group
ischemia-reperfusion (I/R) + Tempol 30 mg/kg i.p, Group
ischemia-reperfusion + Tempol 50 mg/kg i.p. Oxidative Stress Index (OSI) was significantly higher in the ischemia group and the I/R group compared with the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + Tempol 30 mg/kg i.p. and the I/R + Tempol 50 mg/kg i.p. group. Glutathione peroxidase levels were lower in the I/R group than in the I/R + Tempol 30 mg/kg i.p. and the I/R + Tempol 50 mg/kg i.p. group. MDA levels were significantly lower in the I/R + Tempol 30 mg/kg i.p. group and the I/R + Tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + Tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian ischemia reperfusion injury.
This article was published in the following journal.
Name: Canadian journal of physiology and pharmacology
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Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
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