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Cytoplasmic rods and rings in mycophenolic acid treatment.

08:00 EDT 26th July 2017 | BioPortfolio

Summary of "Cytoplasmic rods and rings in mycophenolic acid treatment."

As highlighted in a recent review in Liver International, ribavirin (RBV) retains an important role in the interferon-free era of HCV treatment. In fact, the application of ribavirin has expanded to a broad spectrum of viral infections. One of the most successful examples is the off-label treatment for chronic hepatitis E. This article is protected by copyright. All rights reserved.

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Name: Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
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Medical and Biotech [MESH] Definitions

An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)

Porphyrins with four acetic acid and four propionic acid side chains attached to the pyrrole rings.

DNA of kinetoplasts which are specialized MITOCHONDRIA of trypanosomes and related parasitic protozoa within the order KINETOPLASTIDA. Kinetoplast DNA consists of a complex network of numerous catenated rings of two classes; the first being a large number of small DNA duplex rings, called minicircles, approximately 2000 base pairs in length, and the second being several dozen much larger rings, called maxicircles, approximately 37 kb in length.

Porphyrinogens which are intermediates in heme biosynthesis. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation.

Porphyrins with four methyl and two propionic acid side chains attached to the pyrrole rings.

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