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This Editor's Corner may sound like the title of a mystery novel, but it actually reflects a question I have about the puncta articles that appear in Autophagy. In particular, I am surprised by the number of solicitations sent out for puncta that are either ignored, or, less frequently, declined. It is not that I expect the principal investigator (PI) to find the invitation to write a punctum undeniably attractive. Rather, it is the unilateral decision that it is not worthwhile for graduate students or postdocs who performed the work---and likely wrote at least the first draft of the paper---to write the punctum. In fact, time spent drafting a punctum yields considerable benefits: puncta provide more exposure for the lab, offer opportunities for young scientists to gain additional writing experience, and make a nice (albeit small) addition to a curriculum vitae. It is for the latter reason that I find it particularly disappointing that PIs decide to dismiss the opportunity to write a punctum. I fully understand that for many PIs, adding a punctum will not have a significant impact on a curriculum vitae. Yet for a student or a postdoc who might have a relatively small number of publications at this stage of their career, a punctum (though not a full-fledged research article) can have a more meaningful impact on their C.V.
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Macroautophagy is an intracellular degradation system that involves the de novo formation of membrane structures called autophagosomes, although the detailed process by which membrane lipids are suppl...
The secretory pathway in neurons requires efficient targeting of cargos and regulatory proteins to their release sites. Tomosyn contributes to synapse function by regulating synaptic vesicle (SV) and ...
We have shown that microRNAs-103 and -107(miRs-103/107) positively regulate end-stage autophagy via ensuring dynamin activity in cultured keratinocytes. Most work in end-stage autophagy has been condu...
The study objective is to compare IOP and safety outcomes based on plug placement (upper or lower puncta).
We aim to investigate the effectiveness and safety of nitrous oxide (N2O) in anaesthesia. Hypothesis In patients undergoing anaesthesia for major surgery, avoidance of N2O will reduce ho...
The antineoplastic agent Docetaxel (Taxotere®) is approved for the treatment of patients with metastatic and locally advanced breast cancer and other malignancies. There are 2 frequently ...
Accumulation of intramyocellular lipids (IMCLs) due to increased supply of fatty acids can induce defects in the insulin signaling cascade, causing skeletal muscle insulin resistance. Howe...
In January 2007, the American Congress of Obstetricians and Gynecologists (ACOG) revised its guidelines that now recommend physicians are ethically obligated to fully inform all pregnant w...
In order to become availible to pateints, drugs need to undergo a number of phases of clinical trials to test their efficacy and safty and to then be authorised by the drug approval organistion in each respective country. This is the FDA in the USA and N...