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NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.

08:00 EDT 14th August 2017 | BioPortfolio

Summary of "NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program."

Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions. NFIA and the master transcriptional regulator of adipogenesis, PPARγ, co-localize at the brown-fat-specific enhancers. Moreover, the binding of NFIA precedes and facilitates the binding of PPARγ, leading to increased chromatin accessibility and active transcription. Introduction of NFIA into myoblasts results in brown adipocyte differentiation. Conversely, the brown fat of NFIA-knockout mice displays impaired expression of the brown-fat-specific genes and reciprocal elevation of muscle genes. Finally, expression of NFIA and the brown-fat-specific genes is positively correlated in human brown fat. These results indicate that NFIA activates the cell-type-specific enhancers and facilitates the binding of PPARγ to control the brown fat gene program.

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This article was published in the following journal.

Name: Nature cell biology
ISSN: 1476-4679
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Medical and Biotech [MESH] Definitions

One of the PPAR nuclear transcription factors.

The larger of two types of nuclei in ciliate protozoans. It is the transcriptionally active nucleus of the vegetative cells as distinguished from the smaller transcriptionally inert GERMLINE MICRONUCLEUS.

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