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It is a privilege to reflect upon the impact of advances in basic/translational research in the field over the last 40 years. My approach has been to take a single theme and provide a historical account of notable advances over that time and what impact they might have. The theme of intercellular communication in bone remained of interest to me throughout that time, the main discoveries and how they were made, the major changes in thinking, and how they have influenced concepts of bone remodeling. This article is protected by copyright. All rights reserved.
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The ODYSSEY OUTCOMES trial compared alirocumab with placebo, added to high-intensity or maximum tolerated statin treatment, after acute coronary syndrome (ACS) in 18,924 patients. Alirocumab reduced t...
Pharmacology is one of the cornerstones in health sciences curricula as well as research-oriented biomedical programs in higher education. New educational insights and scientific developments in teach...
Key discoveries in aging research have been made possible with the use of model organisms. Caenorhabditis elegans is a short-lived nematode that has become a well-established system to study aging. Th...
Membranous nephropathy (MN) is the most common cause of a nephrotic syndrome in Caucasian adults. The identification of target antigens in MN in the last decade has had a major impact on the clinical ...
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated...
The study is designed to gather the efficacy, safety and tolerability data in Japanese children 7 to 18 years of age that would support approval of MEDI3250 in Japan.
This study will test whether incentivizing post-workout activities (i.e., reflecting on workouts) is more effective than incentivizing actual workouts. This study has two conditions: refle...
Hemostasis achievement reflecting inflammatory status of the pulp based on cytokine levels
The purpose of the pilot study is to examine the effects of the Incredible Years Baby Programme (IY baby) offered as a universal intervention compared to Usual Care (UC) for parents with i...
The exclusive right, granted by law for a certain number of years, to make and dispose of copies of a literary, musical or artistic work. In the United States the copyright is granted for the life of the author plus 50 years. In the case of a joint work, it is for the life of the last joint author to die, plus 50 years. In either case the copyright runs until the end of the calendar year 50 years after the author's death. (Random House College Dictionary, rev ed; Strong, W.S.: The Copyright Book: a Practical Guide, 1981)
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.
The transitional period before and after MENOPAUSE. Perimenopausal symptoms are associated with irregular MENSTRUAL CYCLE and widely fluctuated hormone levels. They may appear 6 years before menopause and subside 2 to 5 years after menopause.
The personality pattern or syndrome consisting of behavioral and attitudinal characteristics reflecting a preoccupation with the factors of power and authority in interpersonal relationships.
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...