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It is a privilege to reflect upon the impact of advances in basic/translational research in the field over the last 40 years. My approach has been to take a single theme and provide a historical account of notable advances over that time and what impact they might have. The theme of intercellular communication in bone remained of interest to me throughout that time, the main discoveries and how they were made, the major changes in thinking, and how they have influenced concepts of bone remodeling. This article is protected by copyright. All rights reserved.
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Nearly 100 years have passed since Frederick Banting and Charles Best first discovered and purified insulin. Their discovery and subsequent improvements revolutionized the treatment of diabetes, and t...
DNA replication proceeds along spatially and temporally coordinated patterns within the nucleus, thus protecting the genome during the synthesis of new genetic material. While we have been able to vis...
This article proposes a women's health prevention indicator (WHPI) reflecting the combined status of mammography and Papanicolaou (Pap) smear according to the recommendations for age and considering t...
Azotobacter vinelandii has been studied for over 100 years since its discovery as an aerobic nitrogen-fixing organism. This species has proved useful for the study of many different biological syste...
Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although ...
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated...
The study is designed to gather the efficacy, safety and tolerability data in Japanese children 7 to 18 years of age that would support approval of MEDI3250 in Japan.
The purpose of the pilot study is to examine the effects of the Incredible Years Baby Programme (IY baby) offered as a universal intervention compared to Usual Care (UC) for parents with i...
Development of resistance to protease inhibitors in patients under Kaletra as first or second-line therapy.
To evaluate the effects of extra-abdominal repair of the uterine incision compared to intra-abdominal repair, and to study is there superiority of one technique over the other in terms of ...
The exclusive right, granted by law for a certain number of years, to make and dispose of copies of a literary, musical or artistic work. In the United States the copyright is granted for the life of the author plus 50 years. In the case of a joint work, it is for the life of the last joint author to die, plus 50 years. In either case the copyright runs until the end of the calendar year 50 years after the author's death. (Random House College Dictionary, rev ed; Strong, W.S.: The Copyright Book: a Practical Guide, 1981)
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.
The transitional period before and after MENOPAUSE. Perimenopausal symptoms are associated with irregular MENSTRUAL CYCLE and widely fluctuated hormone levels. They may appear 6 years before menopause and subside 2 to 5 years after menopause.
The personality pattern or syndrome consisting of behavioral and attitudinal characteristics reflecting a preoccupation with the factors of power and authority in interpersonal relationships.
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...