Synthetic genomics: the art of design and synthesis.

08:00 EDT 25th March 2017 | BioPortfolio

Summary of "Synthetic genomics: the art of design and synthesis."

Benefited from the rapid development of high-throughput sequencing, genome editing, DNA synthesis and functional genomics, synthetic genomics gains the momentum in this century. The entire genomes of several viruses and one prokaryote have been chemically synthesized and applied to drive normal cellular processes. The first eukaryotic genome synthesis project (Sc2.0) is on-going and about half of the genome has been synthesized and functionally tested. The Human Genome Project-Write (HGP-Write) was proposed in 2016, which pushes the tide of synthetic genomics to a position we have never seen before. Technologies on genome-scale design and DNA synthesis have been rapidly developed, aiming to construct a more predictable and controllable genome at reasonable cost. The generation of synthetic organisms not only has promising applications for industry, environment, healthy and basic researches, but also raises ethic and policy concerns. This review presents the development of synthetic genomics, with emphasis on technologies for whole genome design, synthesis and assembly. We also discussed ethics, prospective and challenge in synthetic genomics. As one of the major branches in synthetic biology, synthetic genomics is still at its infant stage. A lot of excitement will come in the next few years.


Journal Details

This article was published in the following journal.

Name: Sheng wu gong cheng xue bao = Chinese journal of biotechnology
ISSN: 1000-3061
Pages: 331-342


DeepDyve research library

PubMed Articles [11924 Associated PubMed Articles listed on BioPortfolio]

Whole genome engineering by synthesis.

Whole genome engineering is now feasible with the aid of genome editing and synthesis tools. Synthesizing a genome from scratch allows modifications of the genomic structure and function to an extent ...

iBioSim 3: A Tool for Model-Based Genetic Circuit Design.

The iBioSim tool has been developed to facilitate the design of genetic circuits via a model-based design strategy. This paper illustrates the new features incorporated into the tool for DNA circuit d...

Design Methodologies and the Limits of the Engineering-Dominated Conception of Synthetic Biology.

Synthetic biology is described as a new field of biotechnology that models itself on engineering sciences. However, this view of synthetic biology as an engineering field has received criticism, and b...

De novo design of biosynthetic pathways for bacterial production of bulk chemicals and biofuels.

Recent advances in DNA synthesis and computer science have enabled the de novo design of biosynthetic pathways. Numerous computational tools are currently available for searching biosynthetic pathways...

Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.

Shishijimicin A is a scarce marine natural product with highly potent cytotoxicities, making it a potential payload or a lead compound for designed antibody-drug conjugates. Herein, we describe an imp...

Clinical Trials [1878 Associated Clinical Trials listed on BioPortfolio]

Muscle Protein Synthesis Rates After Protein Consumption in Lean, Overweight, and Obese Adults

There are an increasing number of individuals in the United States with obesity, and this is a major health concern with links to many chronic diseases. Impairments in protein metabolism w...

Resistance Exercise and Muscle Protein Synthesis in Obese Adults

Obesity has numerous comorbidities that are associated with exceedingly high healthcare costs. In addition to well- characterized impairments in lipid and glucose metabolism, obesity is as...

A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis

Cholesterol is the precursor of glucocorticoids, mineralocorticoids and sex steroids. Both adrenal and non-adrenal (ovarian + testicular) all steroid hormones are primarily synthesized usi...

CB1R in Synthetic Psychoactive Cannabinoids

The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoact...

Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers

The purpose of this study determine the difference in hemodynamic effects of synthetic and natural caffeine consumption in healthy individuals through blood pressure (central and periphera...

Medical and Biotech [MESH] Definitions

A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.

An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.

Architecture, exterior and interior design, and construction of facilities other than hospitals, e.g., dental schools, medical schools, ambulatory care clinics, and specified units of health care facilities. The concept also includes architecture, design, and construction of specialized contained, controlled, or closed research environments including those of space labs and stations.

The systematic study of the complete DNA sequences (GENOME) of organisms.

The architecture, functional design, and construction of hospitals.

Quick Search


DeepDyve research library

Relevant Topics

Antiretroviral therapy
Standard antiretroviral therapy (ART) consists of the combination of at least three antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease. Huge reductions have been seen in rates of death and suffering whe...

DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Searches Linking to this Article