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An advanced BLT-humanized mouse model for extended HIV-1 cure studies.

08:00 EDT 2nd November 2017 | BioPortfolio

Summary of "An advanced BLT-humanized mouse model for extended HIV-1 cure studies."

Although BLT-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies dependent on endogenous immune responses, most mice develop graft versus host disease (GVHD), limiting their utility for extended HIV cure studies. This study aimed to: 1) Evaluate the GVHD-resistant C57BL/6 Rag2γcCD47 triple knockout (TKO)-BLT mouse as a model to establish HIV-1 latency. 2) Determine whether TKO-BLT mice could be maintained on ART for extended periods of time. 3) Assess the rapidity of viral rebound following therapy interruption.

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Name: AIDS (London, England)
ISSN: 1473-5571
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