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Platelet rescue by macrophage depletion in obese ADAMTS13 deficient mice at risk for thrombotic thrombocytopenic purpura.

07:00 EST 9th November 2017 | BioPortfolio

Summary of "Platelet rescue by macrophage depletion in obese ADAMTS13 deficient mice at risk for thrombotic thrombocytopenic purpura."

Thrombotic thrombocytopenic purpura (TTP) is caused by the absence of ADAMTS13 activity. Thrombocytopenia is presumably related to the formation of microthrombi rich in von Willebrand Factor (VWF) and platelets. Obesity may be a risk factor for TTP; it is associated with abundance of macrophages that may phagocytose platelets.

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This article was published in the following journal.

Name: Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
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