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Heparan sulfate inhibits inflammation and improves wound healing through down-regulating NLRP3 inflammasome in diabetic rats.

07:00 EST 24th November 2017 | BioPortfolio

Summary of "Heparan sulfate inhibits inflammation and improves wound healing through down-regulating NLRP3 inflammasome in diabetic rats."

Heparan sulfate attenuated inflammatory response and improve diabetic wound healing in rats. However, the specific mechanisms that heparan sulfate suppresses inflammation are not clear. Nucleotide binding oligomerization domin-like receptor family pyrin domain containing-3 (NLRP3) is a major receptor involved in innate immune regulation. The present study aimed to elucidate the effect of heparan sulfate on NLRP3 and pro-inflammatory cytokines in diabetic wound.

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This article was published in the following journal.

Name: Journal of diabetes
ISSN: 1753-0407
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