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Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

07:00 EST 22nd November 2017 | BioPortfolio

Summary of "Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice."

Low levels of reactive oxygen species and resulting oxidative protein modifications may play a beneficial role in cellular function under stress conditions. Here we studied the influence of age-dependent protein carbonylation on expression and activity of the anti-oxidative selenoenzyme glutathione peroxidase (GPx) in insulin-deficient Ins2Akita mice and type 2 diabetic obese db/db mice in context of diabetic nephropathy.

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This article was published in the following journal.

Name: Journal of diabetes and its complications
ISSN: 1873-460X
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Medical and Biotech [MESH] Definitions

An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.

A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.

NADPH oxidases that contain two additional EF HAND MOTIFS and an N-terminal PEROXIDASE domain. They are expressed by THYROCYTES and EPITHELIAL CELLS of the kidney, liver, trachea, lung, and glandular tissues such as the testis, pancreas, and prostate. They are critical for the activity of THYROID PEROXIDASE and play a role in the production of thyroid hormones; they may also have antimicrobial activity through the generation of REACTIVE OXYGEN SPECIES.

Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.

A glutathione transferase that catalyzes the conjugation of electrophilic substrates to GLUTATHIONE. This enzyme has been shown to provide cellular protection against redox-mediated damage by FREE RADICALS.

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