Advertisement

Topics

Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease.

07:00 EST 11th December 2017 | BioPortfolio

Summary of "Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease."

Multiple disease processes are associated with cognitive impairment in Parkinson disease (PD), including Lewy bodies, cerebrovascular disease, and Alzheimer disease. It remains unknown whether tau pathology relates to cognition in patients with PD without dementia.

Affiliation

Journal Details

This article was published in the following journal.

Name: JAMA neurology
ISSN: 2168-6157
Pages:

Links

DeepDyve research library

PubMed Articles [18590 Associated PubMed Articles listed on BioPortfolio]

Modifiable Vascular Risk Factors, White Matter Disease, and Cognition in Early Parkinson's Disease.

Dementia in Parkinson's disease (PD) is common and disabling. Identification of modifiable risk factors for it is essential. Vascular risk factors may be associated with cognitive decline in early PD....

The Effects of Exercise on Cognition and Gait in Parkinson's disease: A Scoping Review.

Cognitive and gait deficits are two debilitating symptoms that occur in Parkinson's disease (PD). Importantly, a relationship between cognitive and gait deficits exists in PD, suggesting reliance on c...

Modulating α-synuclein fibril formation using DNA tetrahedron nanostructures.

The small presynaptic protein α-synuclein (α-syn) is involved in the etiology of Parkinson's disease owing to its abnormal misfolding. To date, little information is known on the role of DNA nanostr...

Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease.

Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain.

Non-Motor Symptoms in Early Parkinson's Disease Patients with Different Motor Subtypes and Their Associations with Quality of Life.

This study aims to examine non-motor symptoms in different Parkinson's disease (PD) motor subtypes and their associations with quality of life (QoL).

Clinical Trials [5033 Associated Clinical Trials listed on BioPortfolio]

Florbetapir F 18 PET Imaging of Beta-amyloid in Parkinson's Disease Patients

The primary aim of this study is to compare regional amyloid burden in Parkinson's disease (PD) to normal control subjects. It is hypothesized that there will be significant differences in...

11C-PIB PET/CT in Patients With Parkinson's Disease and Parkinsonian Dementia Syndromes

To evaluate the potential contribution of amyloid burden, as indexed by 11C-Pittsburgh compound B (PiB) retention, to the progression of cognitive impairments in patients with Parkinson's ...

Serotonin and Amyloidopathy

The purpose of this study is to determine if changes in brain serotonin affects the accumulation of amyloid in the brain. The investigators will use brain imaging methods to measure the am...

Identification of Risk Factors Parkinson's Disease by Convergence Strategy

Using this convergence approach from a limited group of subjects with non-diseased controls, patients with Parkinson's disease or related diseases, we will be able to limit the number of p...

Norepinephrine-targeted Therapy for Action Control in Parkinson Disease

The purpose of this study is to find out whether droxidopa, a medication that increases norepinephrine levels, may be effective in improving some aspects of cognition and movement in Parki...

Medical and Biotech [MESH] Definitions

Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.

A precursor to the AMYLOID BETA-PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.

Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE.

Proteins associated with sporadic or familial cases of PARKINSON DISEASE.

A type of extracellularly deposited substance composed of an amyloid protein and additional components including HEPARAN SULFATE PROTEOGLYCAN; LAMININ; COLLAGEN TYPE IV; SERUM AMYLOID P-COMPONENT; and APOLIPOPROTEINS E which together form characteristic amyloid fibrils. The core of amyloid fibrils is formed by the stacking of overlapping beta-pleated sheet domains of the amyloid protein. There are many different amyloid proteins that have been found forming the core of the fibrils in vivo. However, amyloid can be formed from any protein that exposes beta-pleated strand conformations during unfolding or refolding. A common characteristic of amyloid is the ability to bind such dyes as CONGO RED and thioflavine.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...


Searches Linking to this Article