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Claude Bernard - then and now.

07:00 EST 1st January 2017 | BioPortfolio

Summary of "Claude Bernard - then and now."

The early life of Claude Bernard - dreamer and frustrated playwright - reveals no indication of his future scientific aptitude. Cartesian doubt, a principle that he would adhere to lifelong, clouded a failed pharmacy apprenticeship that led to medical studies in Paris - but without great success. Research was his only aim, it was made possible only by a lucrative but unsuccessful arranged marriage. His passion for work and over-riding principles of truth and proof would ultimately allow him to stand out from his peers with recognition by multiple French professional societies - and the wider scientific world. In today's world, the two centuries-long practice of homeopathy illustrates his abhorrence of ''practice without proof'': a dominance by economic factors that is apparent in cancer chemotherapy, where new drug approval is often based on statistics rather than genuine clinical benefit. Bernard was indeed sceptical about the (ab)use of statistics - a caution even more necessary today. His experimental method stands out as a signal principle in research. This was cleverly taken out of context by Emile Zola, who used it to support his ideas on the literary naturalism that appeared in his Rougon-Macquart cycle of books - and that led him to dedicate his book, Le Roman Expérimental, to Claude Bernard himself.

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This article was published in the following journal.

Name: Biologie aujourd'hui
ISSN: 2105-0686
Pages: 157-160

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PubMed Articles [22 Associated PubMed Articles listed on BioPortfolio]

A point mutation in Phe71Ser in glycoprotein IX as a genetic cause of Bernard-Soulier syndrome: case report.

We need to be aware of rare causes of persistent thrombocytopenia as Bernard-Soulier syndrome (BSS). When BSS is suspected based on family history and giant platelets, genetic test for mutations of GP...

A case of undeclared debt? Claude Lévi-Strauss' ambiguities and paradoxes toward analytical psychology.

If his relationship to Sigmund Freud's psychoanalysis has been widely acknowledged, Claude Lévi-Strauss' rapport with C.G. Jung's analytical psychology remains quite obscure. While secondary commenta...

Considerations on the Taxonomy of the Genus Arhuaco Adams and Bernard 1977, and its Relationships with the Genus Pronophila Doubleday 1849 (Nymphalidae, Satyrinae).

Arhuaco Adams & Bernard (1977) is one of the least known genera of Neotropical Satyrinae. It comprises two species and presents an unusual disjunct distribution, with A. ica Adams & Bernard (1977), en...

In Memoriam: Bernard J. Carroll, MD, PhD.

A novel germline mutation in GP1BA gene N-terminal domain in monoallelic Bernard-Soulier syndrome.

Mutations in the GP1BA gene have been associated with platelet-type von Willebrand disease and Bernard-Soulier syndrome. Here, we report a novel GP1BA mutation in a family with autosomal dominant macr...

Clinical Trials [7 Associated Clinical Trials listed on BioPortfolio]

Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice ap...

Kinetics of HIV-RNA Decay in Seminal Plasma of Men Treated by Dolutegravir at the Time of Primary HIV Infection

Sponsor: IMEA - Fondation Internationale Léon Mba C.H.U. Bichat - Claude Bernard 46, Rue Henri Huchard - 75018 PARIS Tél. : 01.40. 25. 63. 65 - Fax : 01.40.25.63.56 Coordinating investi...

New Diagnostic Approach for Congenital Toxoplasmosis

Caused by Toxoplasma gondii, toxoplasmosis is mostly asymptomatic except in immunocompromised individuals and infants infected in utero. Congenital toxoplasmosis (CT) results from the tran...

Activated Protein C in Severe Acute Pancreatitis

Activated protein C (APC)has been shown to reduce mortality in severe sepsis(Bernard et al. 2001b). The clinical picture of severe acute pancreatitis (AP) is similar to that of sepsis. The...

Post Traumatic Stress Disorder and Neural Mechanisms Involved in Its Treatment

The post traumatic stress disorder PTSD arises when the physiological response to stress does not come to its term. This study aims to explore the cognitive, psycho physiological and cereb...

Medical and Biotech [MESH] Definitions

Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.

A familial coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, and impaired prothrombin consumption.

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