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Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn.

07:00 EST 14th December 2017 | BioPortfolio

Summary of "Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn."

Long non-coding RNAs, produced from distinct regions of the chromosomes, are emerging as new key players in several important biological processes. The long non-coding RNAs add a new layer of complexity to cellular regulatory pathways, from transcription to cellular trafficking or chromatin remodeling. More than 25 years ago, the discovery of a transcriptional activity at telomeres of protozoa ended the long-lasting belief that telomeres were transcriptionally silent. Since then, progressively accumulating evidences established that production of TElomeric Repeat-containing RNA (TERRA) was a general feature of eukaryotic cells. Whether TERRA molecules always originate from the telomeres or whether they can be transcribed from internal telomeric repeats as well is however still a matter of debate. Whether TERRA transcripts always localize to telomeres and play similar roles in all eukaryotic cells is also unclear. We review the studies on TERRA localization in the cell, its composition and some aspects of its transcriptional regulation to summarize the current knowledge and controversies about the genomic origin of TERRA, with a focus on human and mouse TERRA. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: The FEBS journal
ISSN: 1742-4658
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