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The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility.

07:00 EST 20th December 2017 | BioPortfolio

Summary of "The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility."

Recently, the expression of proteinase-activated receptor 2 (PAR2) has been shown to be essential for activin receptor-like kinase 5 (ALK5)/SMAD-mediated signaling and cell migration by transforming growth factor (TGF)-β1. However, it is not known whether activation of non-SMAD TGF-β signaling (e.g., RAS-RAF-MEK-extracellular signal-regulated kinase (ERK) signaling) is required for cell migration and whether it is also dependent on PAR2.

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Name: International journal of molecular sciences
ISSN: 1422-0067
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