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Metformin, beta-cell development, and novel processes following beta-cell ablation in zebrafish.

07:00 EST 22nd December 2017 | BioPortfolio

Summary of "Metformin, beta-cell development, and novel processes following beta-cell ablation in zebrafish."

Type 1 and 2 diabetes are characterized by a loss of insulin-producing beta-cells. Current treatments help maintain blood glucose levels but cannot provide a cure. As such, a vital target for the cure of diabetes is a way to restore beta-cell mass. The drug metformin can protect cultured beta-cells/islets from hyperglycemia-induced dysfunction and death. Further, treatment of pregnant mice with metformin results in an enhanced beta-cell fraction in the embryos; however, whether this occurs via a direct effect is unknown.

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Name: Endocrine
ISSN: 1559-0100
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