Advertisement

Topics

Probing the Particulate Microstructure of the Aerodynamic Particle Size Distribution of Dry Powder Inhaler Combination Products.

07:00 EST 28th December 2017 | BioPortfolio

Summary of "Probing the Particulate Microstructure of the Aerodynamic Particle Size Distribution of Dry Powder Inhaler Combination Products."

The in vitro aerosol performance of two combination dry powder inhaler (DPI) products, Foster® NEXThaler® and Seretide® Diskus® were investigated with single particle aerosol mass spectrometry (SPAMS). The in-vitro pharmaceutical performance is markedly different for both inhalers. Foster® NEXThaler® generates a higher fine particle fraction (FPF <5 μm) and a much higher relative extra fine particle fraction (eFPF <2 μm). In terms of the composition of the aerodynamic particle size distribution (APSD), it could be verified with SPAMS that overall Foster® NEXThaler® emits a significantly higher number of fine and extra fine particles with a median aerodynamic diameter (MAD) of 2.1 μm while Seretide® Diskus® had a larger MAD of 3.1 μm. Additionally, the interactions between the two active pharmaceutical ingredients (APIs) in both products are different. While Seretide® emits a significant (37%) number of co-associated API particles, only a negligible number of co-associated API particles were found in Foster® NEXThaler® (<1%). A major difference with Foster® NEXThaler® is that it contains magnesium stearate (MgSt) as a second excipient besides lactose in a so-called 'dual excipient' platform. The data generated using SPAMS suggested that nearly all of the beclomethasone dipropionate particles in Foster® NEXThaler® also contain MgSt and must therefore be co-associated with this additional excipient. This may help explain why beclomethasone dipropionate in Foster® NEXThaler® forms less particle co-associations with the second API, formoterol fumarate, shows a lower cohesive strength in respect to beclomethasone itself and why both APIs exhibit superior detachment from the carrier as evidenced by the increased eFPF and smaller MAD.

Affiliation

Journal Details

This article was published in the following journal.

Name: International journal of pharmaceutics
ISSN: 1873-3476
Pages:

Links

DeepDyve research library

PubMed Articles [11366 Associated PubMed Articles listed on BioPortfolio]

Development, characterization, and in vitro testing of co-delivered antimicrobial dry powder formulation for the treatment of Pseudomonas aeruginosa biofilms.

Pseudomonas aeruginosa is an opportunistic bacteria responsible for recurrent lung infections. Previously, we demonstrated that certain materials improved the activity of tobramycin (Tob) against P. a...

PBDE emission from E-wastes during the pyrolytic process: Emission factor, compositional profile, size distribution, and gas-particle partitioning.

Polybrominated diphenyl ether (PBDE) pollution in E-waste recycling areas has garnered great concern by scientists, the government and the public. In the current study, two typical kinds of E-wastes (...

Particle size distribution of selected electronic nicotine delivery system products.

Dosimetry models can be used to predict the dose of inhaled material, but they require several parameters including particle size distribution. The reported particle size distributions for aerosols fr...

Screening study of four environmentally relevant microplastic pollutants: Uptake and effects on Daphnia magna and Artemia franciscana.

This study investigated four different environmentally relevant microplastic (MP) pollutants which were derived from two facial cleansers, a plastic bag and polyethylene textile fleece. The mean size ...

Control of the Size of Silver Nanoparticles and Release of Silver in Heat Treated SiO₂-Ag Composite Powders.

The growth of silver nanoparticles, the activation energy for silver particle growth, and the release of silver species in heat treated SiO 2 -Ag composite powders are investigated. The silver particl...

Clinical Trials [2899 Associated Clinical Trials listed on BioPortfolio]

Asthma & Exposure to Peaks in Particulate Air Pollution

We are testing the following two hypotheses: 1) Peaks in hourly exposures to airborne particulate matter (PM) of outdoor origin will be more closely associated with acute asthmatic respons...

Pair Production PET Imaging to Detect Particle Distribution in Patients Undergoing Yttrium-90 Radioembolization

The primary goal of the study is to see if the PET/CT will be able to determine the precise location of the Y-90 particles within the liver and within the tumors. We hope to use this infor...

In Vivo Wear of All-ceramic and Metal-ceramic Crowns and Their Enamel Antagonists After Three Years

This study aims determine the wear rates of enamel versus enamel and enamel versus ceramic in human beings in relation to the microstructure of the ceramic material. Specific aims of the ...

Association of Air Quality and Myocardial Infarction

Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. ...

Analysis of Enamel Wear Against Ceramic Restorations

1. To characterize the microstructure (fracture toughness, particle size of ceramic, and inter-particle spacing) of three ceramic materials 2. To test the hypothesis that lower fra...

Medical and Biotech [MESH] Definitions

Relating to the size of solids.

Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES.

A device that delivers medication to the lungs in the form of a dry powder.

An analytical technique for measuring particle size of molecules that are less than a micron in diameter dispersed or dissolved in a liquid.

The probability distribution associated with two mutually exclusive outcomes; used to model cumulative incidence rates and prevalence rates. The Bernoulli distribution is a special case of binomial distribution.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Asthma
Asthma is caused by inflammation of small tubes, called bronchi, which carry air in and out of the lungs. If you have asthma, the bronchi will be inflamed and more sensitive than normal.  When you come into contact with something that irritates your...


Searches Linking to this Article