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Design and evaluation of bi-layer pump tablet of flurbiprofen solid dispersion for zero-order controlled delivery.

07:00 EST 29th December 2017 | BioPortfolio

Summary of "Design and evaluation of bi-layer pump tablet of flurbiprofen solid dispersion for zero-order controlled delivery."

In this study, a bi-layer osmotic pump tablet (OPT) of Flurbiprofen (FP) solid dispersions (SDs) was developed to increase the solubility of the poorly soluble drug and control drug release at a constant rate. Based on the thermodynamic properties investigation of the drug, the carrier and the calculation of the solubility parameters, the FP-SD was prepared by hot melt extrusion (HME) technique with the carrier of PVPVA64. Then central composite design-response surface methodology (CCD-RSM) was used to evaluate the influence of factors on the responses. Consequently, PVP VA64 was selected as the carrier for preparing FP-SD. The results of DSC and X-Ray confirmed that FP in FP-SD was in amorphous state. FTIR indicated that the intermolecular hydrogen bond probably formed between FP and PVP VA64 in FP-SD. And correlation of release profiles to zero-order kinetics was significant (R2=0.9939). The mathematical models had good predictability because of the deviation was less than 1% between predicted value and measured value. These results demonstrated that FP-SD OPTs successfully increased the solubility of FP and controlled the release of FP at a constant rate.

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This article was published in the following journal.

Name: Journal of pharmaceutical sciences
ISSN: 1520-6017
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