Quantifying NMR relaxation correlation and exchange in articular cartilage with time domain analysis.

07:00 EST 19th December 2017 | BioPortfolio

Summary of "Quantifying NMR relaxation correlation and exchange in articular cartilage with time domain analysis."

Measured nuclear magnetic resonance (NMR) transverse relaxation data in articular cartilage has been shown to be multi-exponential and correlated to the health of the tissue. The observed relaxation rates are dependent on experimental parameters such as solvent, data acquisition methods, data analysis methods, and alignment to the magnetic field. In this study, we show that diffusive exchange occurs in porcine articular cartilage and impacts the observed relaxation rates in T1-T2 correlation experiments. By using time domain analysis of T2-T2 exchange spectroscopy, the diffusive exchange time can be quantified by measurements that use a single mixing time. Measured characteristic times for exchange are commensurate with T1 in this material and so impacts the observed T1 behavior. The approach used here allows for reliable quantification of NMR relaxation behavior in cartilage in the presence of diffusive fluid exchange between two environments.


Journal Details

This article was published in the following journal.

Name: Journal of magnetic resonance (San Diego, Calif. : 1997)
ISSN: 1096-0856
Pages: 82-90


DeepDyve research library

PubMed Articles [15217 Associated PubMed Articles listed on BioPortfolio]

Quantitative measurement of T2, T1ρ and T1 relaxation times in articular cartilage and cartilage-bone interface by SE and UTE imaging at microscopic resolution.

Both spin-echo (SE) and ultra-short echo (UTE) based MRI sequences were used on a 7 T µMRI system to quantify T2, T1ρ and T1 relaxation times from articular cartilage to the cartilage-bone interfa...

Cartilage-on-cartilage contact: Effect of compressive loading on tissue deformations and structural integrity of bovine articular cartilage.

This study aims to characterize the deformations in articular cartilage under compressive loading and link these to changes in the extracellular matrix constituents described by magnetic resonance ima...

Quantitative MRI Helps to Detect Hip Ischemia: Preclinical Model of Legg-Calvé-Perthes Disease.

Purpose To determine whether quantitative MRI relaxation time mapping techniques can help to detect ischemic injury to the developing femoral head. Materials and Methods For this prospective animal st...

Compressed sensing acceleration of biexponential 3D-T relaxation mapping of knee cartilage.

Use compressed sensing (CS) for 3D biexponential spin-lattice relaxation time in the rotating frame (T ) mapping of knee cartilage, reducing the total scan time and maintaining the quality of estimate...

Subjects with medial and lateral tibiofemoral articular cartilage defects do not alter compartmental loading during walking.

Healthy cartilage is essential for optimal joint function. Although, articular cartilage defects are highly prevalent in the active population and hamper joint function, the effect of articular cartil...

Clinical Trials [4028 Associated Clinical Trials listed on BioPortfolio]

Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration

The Cartilage Autograft Implantation System (CAIS) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight...

Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions

This study is aimed at evaluating the feasibility and effectiveness of a completely natural tissue engineered cartilage, composed of a self-made tissue engineered oriented scaffold and aut...

Randomized, Multi-center Phase II Clinical Trial for the Regeneration of Cartilage Lesions in the Knee

The purpose of this study is to investigate the efficacy of an engineered cartilage transplant (N-TEC) in comparison to a cell-activated matrix (N-CAM) for the treatment of articular carti...

Study of the Treatment of Articular Repair (STAR)

This study is a prospective, longitudinal, multi-center, within patient evaluation of patients with articular cartilage defects of the knee who have had an inadequate response to a prior n...

NeoCart Phase 2 Clinical Trial

The objective of this study is to gather additional information regarding the performance of NeoCart to fill articular cartilage defects in the knee.

Medical and Biotech [MESH] Definitions

Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.

A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).

A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.

A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.

A type of osteochondritis in which articular cartilage and associated bone becomes partially or totally detached to form joint loose bodies. Affects mainly the knee, ankle, and elbow joints.

Quick Search


DeepDyve research library

Relevant Topic

Mergers & Acquisitions
Commercial and market reports on mergers and acquisitions in the biotechnology, pharmaceutical, medical device and life-science industries. Mergers and acquisitions (abbreviated M&A;) is an aspect of corporate strategy, corporate finance and manageme...

Searches Linking to this Article