Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2.

07:00 EST 3rd January 2018 | BioPortfolio

Summary of "Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2."

Heparan sulfate proteoglycans are ubiquitously expressed on cell surfaces and in extracellular matrices, and are engaged in heparin-binding growth factor-related signal transduction. Thus, changes in the amounts, structures, and chain lengths of heparan sulfate have profound effects on aspects of cell growth controlled by heparin-binding growth factors such as FGF2. Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate. Unlike EXT1, EXT2, and EXTL3, EXTL2 functions chain termination of heparan sulfate. Here, we examined the importance of EXTL2 in FGF2-dependent signaling.


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This article was published in the following journal.

Name: Biochimica et biophysica acta
ISSN: 0006-3002


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