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Myeloproliferative Neoplasms May Be Sensitive to Dual BET/JAK Inhibition.

07:00 EST 5th January 2018 | BioPortfolio

Summary of "Myeloproliferative Neoplasms May Be Sensitive to Dual BET/JAK Inhibition."

In myeloproliferative neoplasms (MPN) chromatin changes promote NF-κB signaling to drive inflammation.

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This article was published in the following journal.

Name: Cancer discovery
ISSN: 2159-8290
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Medical and Biotech [MESH] Definitions

Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.

A leukemia affecting young children characterized by SPLENOMEGALY, enlarged lymph nodes, rashes, and hemorrhages. Traditionally classed as a myeloproliferative disease, it is now considered a mixed myeloproliferative-mylelodysplastic disorder.

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.

A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide. EC 1.4.3.6.

A subtype of equilibrative nucleoside transporter proteins that is sensitive to inhibition by 4-nitrobenzylthioinosine.

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