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Topical administration of regorafenib eye drops: Phase I dose-escalation study in healthy volunteers.

07:00 EST 9th January 2018 | BioPortfolio

Summary of "Topical administration of regorafenib eye drops: Phase I dose-escalation study in healthy volunteers."

Regorafenib is a multi-kinase inhibitor under investigation for use in neovascular age-related macular degeneration. In this Phase I study, regorafenib eye drops were administered to healthy volunteers to provide information on safety, tolerability and systemic exposure.

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This article was published in the following journal.

Name: British journal of clinical pharmacology
ISSN: 1365-2125
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Medical and Biotech [MESH] Definitions

The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from irrigation in that the irrigate is removed within minutes, but the instillate is left in place.

Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.

The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

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