Track topics on Twitter Track topics that are important to you
The properties of a dendritic polyelectrolyte in equilibrium with a reservoir of monovalent salts are investigated using the cell model and the Poisson-Boltzmann-Flory theory. Within this approach we use the Debye-Hückel approximation to solve the Poisson-Boltzmann equation and minimize the semi-grand potential of the system with respect to the size of the molecule which enables us to inspect its conformations as well as the electric field, the ionic density profile, the overall charge density, the effective charge of the dendrimer and the osmotic pressure based on their response to the salt concentration and the dendrimer charge. The model predicts pronounced trapping of salt ions, a local charge neutrality and a zero electric field in the volume of the molecule as well as oscillations of the density profiles and the electric field in the vicinity of the dendrimer-bulk interface. As a result of ion trapping and screening of Coulomb interactions monovalent salts are found to have a minor effect on the size of the dendrimer. Specifically, the dendrimer exists in slightly swollen states as compared to the neutral molecule which indicates that the conformational properties of the polyelectrolyte depend weakly on monovalent salts. These observations harmonise with the equilibrium behavior of the dendrimer pressure, the internal pressure and the bulk pressure, respectively.
This article was published in the following journal.
Name: Physical chemistry chemical physics : PCCP
The nonlocal modified Poisson-Boltzmann equation (NMPBE) is one important variant of a commonly-used dielectric continuum model, the Poisson-Boltzmann equation (PBE), for computing electrostatics of b...
The solution of the Poisson equation is a crucial step in electronic structure calculations, yielding the electrostatic potential-a key component of the quantum mechanical Hamiltonian. In recent decad...
We discuss recent investigations of the interaction of polyelectrolytes with proteins. In particular, we review our recent studies on the interaction of simple proteins as human serum albumin (HSA) or...
In this study, an ab initio fragment molecular orbital (FMO) methodology was developed to evaluate the solvent effects on electrostatic interactions, which make a significant contribution to the physi...
Poisson's ratio has not been experimentally measured earlier for meniscus in compression. It is however an important intrinsic material property needed in biomechanical analysis and computational mode...
The purpose of this study is to determine if the intra-tumoral injection of a subject's own dendritic cells after cryotherapy of the prostate is a safe and effective treatment for advanced...
This research is being determine whether vaccinations with your own immune cells called " dendritic cells " can activate your immune system to fight your brain tumor.
The purpose of this study is to assess the safety and activity of DC/PC3, a dendritic cell vaccine used as immunotherapy for prostate cancer. The vaccine is made with each participants' o...
Open, randomized study of a trivalent dendritic cell therapy compared to standard therapy in primary treated patients with IDH wild-type, MGMT-promotor methylated glioblastoma. The IMP is ...
To define the safety and efficacy of sibling-supplied, HIV antigen-pulsed dendritic cells in increasing the immune response in HIV-infected patients. Dendritic cells are a type of white b...
Naturally-occurring or artificially made water-soluble POLYMERS whose repeating units are ionizable. Polyelectrolytes demonstrate attributes that are typical of salts, such as electrical conductivity, and typical of polymers, such as viscosity.
Non-hematopoietic cells, with extensive dendritic processes, found in the primary and secondary follicles of lymphoid tissue (the B cell zones). They are different from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL STEM CELLS and are negative for class II MHC antigen and do not process or present antigen like the conventional dendritic cells do. Instead, follicular dendritic cells have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY COMPLEXES on their surfaces for long periods for recognition by B-CELLS.
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and CYBERNETICS.
A psychological theory based on dimensions or categories used by a given person in describing or explaining the personality and behavior of others or of himself. The basic idea is that different people will use consistently different categories. The theory was formulated in the fifties by George Kelly. Two tests devised by him are the role construct repertory test and the repertory grid test. (From Stuart Sutherland, The International Dictionary of Psychology, 1989)