Ependymoma Superenhancer Profiling Reveals Potential Therapeutic Targets.

07:00 EST 12th January 2018 | BioPortfolio

Summary of "Ependymoma Superenhancer Profiling Reveals Potential Therapeutic Targets."

Ependymoma superenhancer landscapes delineate molecular subgroups and define transcriptional circuitries.


Journal Details

This article was published in the following journal.

Name: Cancer discovery
ISSN: 2159-8290


DeepDyve research library

PubMed Articles [18676 Associated PubMed Articles listed on BioPortfolio]

The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets.

Multiple myeloma (MM), a malignant plasma cell disorder, is still an incurable disease. Thus, the identification of novel therapeutic targets is of utmost importance. Here, we evaluated the peripheral...

Analysis of Multimodal Intraoperative Monitoring During Intramedullary Spinal Ependymoma Surgery.

To evaluate the validity of intraoperative somatosensory-evoked potential (SSEP) and motor-evoked potential (MEP) monitoring according to two different warning criteria during 6 months from intramedul...

CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets.

Although we have seen tremendous advances in the comprehension of CKD-MBD pathophysiology during the last few years, this was not accompanied by a significant change in mortality rate and quality of l...

EGFL7 - a potential therapeutic target for multiple sclerosis?

A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation.

Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorige...

Clinical Trials [4823 Associated Clinical Trials listed on BioPortfolio]

Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy

This is a prospective study investigating the disease course of patients with colorectal cancer that have had their cancer spread to their liver. The aim of this study is find potential bi...

Genomic and Proteomic Profiling Targets Influenced Treatment in Metastatic Breast Cancer

The primary objective is to examine the impact on progression-free survival of targeted therapy for breast cancer suggested by proteomic and genomic profiling.

PRecISion Medicine for Children With Cancer

This is a multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for childr...

Profiling of Oncology Patients as Part of Clinical Care and Research

The era of precision medicine is an exciting time for clinicians, scientists and patients alike. The increasing appreciation and identification of specific mutations that drive cancers, le...

Outcomes and Risk in People With Ependymoma

Background: Ependymoma is a rare type of primary brain or spine tumor. That means that it starts in the brain or spine. These tumors affect both children and adults. Researchers want to s...

Medical and Biotech [MESH] Definitions

The process of finding chemicals for potential therapeutic use.

An analytical method for detecting and measuring FLUORESCENCE in compounds or targets such as cells, proteins, or nucleotides, or targets previously labeled with FLUORESCENCE AGENTS.

A form of antibodies (scFv) consisting of the variable regions of only the heavy and light chains, connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.

Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)

A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Quick Search


DeepDyve research library

Relevant Topic

Brain Cancer
According to the American Brain Tumor Association, just over 24,000 patients will be diagnosed with a primary malignant brain tumour during 2012 in the US alone. Some 80% of primary malignant brain tumours are gliomas, a broad term which includes all tum...

Searches Linking to this Article