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Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients.

07:00 EST 1st January 2018 | BioPortfolio

Summary of "Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients."

Smith-Magenis syndrome (SMS) causes sleep disturbance that is related to an abnormal melatonin profile. It is not clear how the genomic disorder leads to a disturbed synchronization of the sleep/wake rhythm in SMS patients. To evaluate the integrity of the intrinsically photosensitive retinal ganglion cell (ipRGC)/melanopsin system, the transducers of the light-inhibitory effect on pineal melatonin synthesis, we recorded pupillary light responses (PLR) in SMS patients.

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This article was published in the following journal.

Name: Investigative ophthalmology & visual science
ISSN: 1552-5783
Pages: 362-369

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