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Chemogenetic Tools for Causal Cellular and Neuronal Biology.

07:00 EST 1st January 2018 | BioPortfolio

Summary of "Chemogenetic Tools for Causal Cellular and Neuronal Biology."

Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.

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Journal Details

This article was published in the following journal.

Name: Physiological reviews
ISSN: 1522-1210
Pages: 391-418

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Medical and Biotech [MESH] Definitions

Clusters of neuronal cell bodies in invertebrates. Invertebrate ganglia may also contain neuronal processes and non-neuronal supporting cells. Many invertebrate ganglia are favorable subjects for research because they have small numbers of functional neuronal types which can be identified from one animal to another.

The study of the structure, behavior, growth, reproduction, and pathology of cells; and the function and chemistry of cellular components.

Formation of neuronal processes (AXONS; NEURITES) toward a target cell.

The field of biology which deals with the process of the growth and differentiation of an organism.

One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for nicotine over muscarine. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, molecular biology, and biophysical properties of the channels.

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