Parathyroid hormone-related protein contributes to early healing of Habu-SnakeVenom-induced glomerulonephritis in mice.

07:00 EST 15th January 2018 | BioPortfolio

Summary of "Parathyroid hormone-related protein contributes to early healing of Habu-SnakeVenom-induced glomerulonephritis in mice."

Proliferative glomerulonephritis is characterized by local inflammation and mesangial cell deterioration, followed by mesangial proliferation and glomerular healing. Parathyroid-hormone-related peptide (PTHrP) is a mesangial cytokine-like growth factor implicated in mesangial proliferation and survival. No data are available about its role in glomerulonephritis. Herein, we analyzed the expression and role of PTHrP in glomerular inflammation and healing in an experimental model of glomerulonephritis induced by intravenous injection of Habu-snake venom in mice. The temporal analysis showed marked renal damage in the first days after venom injection and beginning of recovery within seven days. Glomerular expression of PTHrP (transcript and protein) was observed in the very early phase after venom injection (day-1 to day-3), along with an inflammatory environment. The inactivation of secreted PTHrP with PTHrP-neutralizing antibody (PTH2E11, 120 μg i.p. daily) reduced the markers of local inflammation (expression of MCP-1, RANTES, Cox-2, IL-6, and macrophage infiltration) and abolished the expression of PTHrP itself. Moreover, the glomerular cell proliferation was hampered, and the healing process was prevented on day-7 post-venom injection. These results show that PTHrP has antinomic actions in glomerulonephritis, participating to both the pro-inflammatory condition and the healing process. Our work reveals the essential role of PTHrP in the early glomerular repair in an experimental model of glomerulonephritis.


Journal Details

This article was published in the following journal.

Name: The American journal of pathology
ISSN: 1525-2191


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