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The instability of hydroxyl peroxyesters, the elusive Criegee intermediates of the Bayer-Villiger rearrangement, can be alleviated by selective deactivation of stereoelectronic effects that promote the 1,2-alkyl shift. Stable cyclic Criegee intermediates constrained within a five-membered ring can be prepared by mild reduction of respective hydroperoxyl peroxyesters (β-hydroperoxy-β-peroxylactones) which were formed in high yields in reaction of β-ketoesters with BF3·Et2O/H2O2.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
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Ordered rearrangement of T-cell variable gene regions coding for the antigen receptors.
Process for making, building or constructing a physical object from a three-dimensional digital model by laying down many successive thin layers of building material.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.
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