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Uptake and metabolism of the antidepressants sertraline, clomipramine and trazodone in a garden cress (Lepidium sativum) model.

07:00 EST 10th February 2018 | BioPortfolio

Summary of "Uptake and metabolism of the antidepressants sertraline, clomipramine and trazodone in a garden cress (Lepidium sativum) model."

Environmental contamination with pharmaceuticals has received growing attention in recent years. Several studies describe the presence of traces of drugs in water bodies and soils and their impacts on non-target organisms including plants. Due to these facts investigations of the uptake and metabolism of pharmaceuticals in organisms is an emerging research area. The present study demonstrates the analysis of three selected antidepressants (sertraline, clomipramine and trazodone) as well as metabolites and transformation products in a cress model (Lepidium sativum). Cress was treated with tap water containing 10 mg L-1 of the parent drugs. Employing an analytical approach based on HPLC coupled with quadrupole-time-of-flight or Orbitrap mass spectrometry in MS and MS² mode, in total 14 substances were identified in the cress extracts. All three parent drugs were taken up by the cress and translocated from the roots to the leaves in specific patterns. In addition to this, eleven metabolite species were identified. They were generated by hydroxylation, demethylation, conjugation with amino acids or combinations of these mechanisms. Finally, the inclusion of control cultures in the experimental setup allowed for a differentiation of "true" metabolites generated by the cress and transformation products generated by plant-independent mechanisms. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Electrophoresis
ISSN: 1522-2683
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